Risk of low calcium and high magnesium in continuous warm hyperkalemic cardioplegia
| Autor: | Yoshinobu Nakamura, Hiroaki Kuroda, Shigetsugu Ohgi, Naoaki Takemoto, Tohru Mori |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Cardiac function curve medicine.medical_specialty Bicarbonate chemistry.chemical_element Myocardial Reperfusion Injury Calcium chemistry.chemical_compound Risk Factors Internal medicine medicine Animals Magnesium Rats Wistar Tromethamine Cardioplegic Solutions Dose-Response Relationship Drug Hypocalcemia business.industry Myocardium Metabolic disorder Temperature medicine.disease Rats Microscopy Electron Dose–response relationship Glucose Endocrinology chemistry Anesthesia High magnesium Heart Arrest Induced Surgery Hypermagnesemia Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of Thoracic Surgery. 68:1295-1301 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(99)00679-7 |
| Popis: | Background . The recent introduction of operations on a warm heart has prompted clinical reports on the usefulness of continuous blood cardioplegia, but no in-depth basic evaluation of continuous cardioplegia has been done. The cardioprotective effects of magnesium (Mg) and calcium (Ca) in continuous warm hyperkalemic crystalloid cardioplegic solutions were investigated in an isolated rat heart model. Methods . Isolated rat hearts were arrested for 180 minutes at 37°C with a continuous warm hyperkalemic (20 mmol/L) modified Krebs-Henseleit bicarbonate buffer solution containing 1.2, 8.0, or 16.0 mmol/L of Mg and 0.1 to 2.5 mmol/L of Ca in different concentrations. Recovery of cardiac function and tissue damage were estimated. Results . For each Mg concentration, the percentage recovery of aortic flow generated dose-response curves depending on Ca concentration. However, as Mg concentration increased, the recovery of aortic flow decreased in the groups with 0.5 mmol/L of Ca or less. Conclusions . In continuous warm cardioplegia the combination of low Ca and high Mg concentration caused severe cardiac injury, and normal Ca concentration avoids cardiac injury regardless of Mg concentrations. |
| Databáze: | OpenAIRE |
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