Assessment of ocular microcirculation in patients with end-stage kidney disease
| Autor: | Tomoaki Shiba, Hironori Osamura, Shun Kumashiro, Mao Takahashi, Tadashi Matsumoto, Ken Sakai, Tetsushi Arimura, Yuichi Hori |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Optic Disk 030232 urology & nephrology Urology Renal function Polysomnography Hematocrit Microcirculation 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine Laser-Doppler Flowmetry medicine Humans Retrospective Studies Creatinine medicine.diagnostic_test Choroid business.industry Middle Aged medicine.disease eye diseases Sensory Systems Ophthalmology Cross-Sectional Studies medicine.anatomical_structure chemistry Regional Blood Flow 030221 ophthalmology & optometry Kidney Failure Chronic Female sense organs business Blood Flow Velocity Follow-Up Studies Glomerular Filtration Rate Kidney disease |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 256:2335-2340 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-018-4137-z |
| Popis: | To determine the impact that end-stage kidney disease (ESKD) has on ocular microcirculation in the optic nerve head (ONH) and choroid area shown by laser speckle flowgraphy (LSFG). We studied 24 consecutive Japanese patients with ESKD who visited the department of Nephrology at our hospital and 55 age- and gender-matched subjects who had undergone polysomnography. The mean blur rates (MBRs) in vessels (MBR-Vessel), in the tissue (MBR-Tissue), throughout the ONH (MBR-All), and throughout the choroid (MBR-Choroid) were analyzed. We divided the MBR-Tissue into four sections (superior, temporal, inferior, and nasal). The results of systemic and ocular parameters were compared between the ESKD patients and control subjects. We performed single and multiple regression analyses to determine the MBR section(s) that correlated most strongly with serum creatinine and the estimated glomerular filtration rate (eGFR) and to identify the independent factors for selected MBR sections in the ESKD patients. All sections of the ONH in the ESKD patients were significantly lower than those in the control subjects. MBR-Choroid was not significantly different between the control and ESKD groups. The single regression analyses revealed that MBR-Tissue had the strongest correlations with creatinine and the eGFR. The multiple regression analyses revealed hematocrit, creatinine, and eGFR as factors independently contributing to the MBR-Tissue. The inferior section of MBR-Tissue was most strongly correlated with creatinine and the eGFR. The MBRs in the ONH of the ESKD patients decrease compared with control subjects and the inferior section of MBR-Tissue is correlated with serum creatinine and eGFR. |
| Databáze: | OpenAIRE |
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