Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT
| Autor: | Massimo F. Martelli, Piyanuch Kongtim, Paul O'Donnell, Monzr M. Al Malki, Philippe Lewalle, Rupert Handgretinger, Jorge Gayoso, Michael Maschan, Christoph Schmid, Norbert Claude Gorin, Andrea Bacigalupo, Denis-Claude Roy, Karen K. Ballen, Hillard M. Lazarus, Arnon Nagler, Myriam Labopin, Stephan Mielke, Alexandros Spyridonidis, Fabio Ciceri, A. Ruggeri, Asad Bashey, Yolande Arnault, Stefan O. Ciurea, Leo Luznik, Sebastian Giebel, Frédéric Baron, Mohamad Mohty, Ephraim J. Fuchs, Bipin N. Savani, Scott D. Solomon, Bhagirathbhai Dholaria, Franco Aversa, Xiao-Jun Huang, Didier Blaise, Franco Locatelli, Luca Castagna, Jordi Esteve, Patrick Ben Soussan, Rizwan Romee |
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| Přispěvatelé: | Dholaria, B., Savani, B. N., Labopin, M., Luznik, L., Ruggeri, A., Mielke, S., Al Malki, M. M., Kongtim, P., Fuchs, E., Huang, X. -J., Locatelli, F., Aversa, F., Castagna, L., Bacigalupo, A., Martelli, M., Blaise, D., Soussan, P. B., Arnault, Y., Handgretinger, R., Roy, D. -C., O'Donnell, P., Bashey, A., Solomon, S., Romee, R., Lewalle, P., Gayoso, J., Maschan, M., Lazarus, H. M., Ballen, K., Giebel, S., Baron, F., Ciceri, F., Esteve, J., Gorin, N. -C., Spyridonidis, A., Schmid, C., Ciurea, S. O., Nagler, A., Mohty, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Consensus medicine.medical_treatment Immunology Graft vs Host Disease Hematopoietic stem cell transplantation Cardiorespiratory Medicine and Haematology Regenerative Medicine Donor lymphocyte infusion Guideline Article Rare Diseases consensus hematopietic stem cell transplantation lymphocytes Internal medicine Humans Medicine ddc:610 Lymphocytes Prospective Studies Cancer Retrospective Studies Transplantation Acute leukemia Chemotherapy business.industry Prevention Inflammatory and immune system Hematopoietic Stem Cell Transplantation Hematology Stem Cell Research Donor Lymphocytes Minimal residual disease Granulocyte colony-stimulating factor Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA DLI business Hématologie |
| Zdroj: | Haematologica Haematologica, vol 105, iss 1 Haematologica, 105 (1 |
| Popis: | Donor lymphocyte infusion has been used in the management of relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation. It can eradicate minimal residual disease or be used to rescue a hematologic relapse, being able to induce durable remissions in a subset of patients. With the increased use of haploidentical hematopoietic cell transplantation, there is renewed interest in the use of donor lymphocytes to either treat or prevent disease relapse post transplant. Published retrospective and small prospective studies have shown encouraging results with therapeutic donor lymphocyte infusion in different haploidentical transplantation platforms. In this consensus paper, finalized on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize the available evidence on the use of donor lymphocyte infusion from haploidentical donor, and provide recommendations on its therapeutic, pre-emptive and prophylactic use in clinical practice. SCOPUS: re.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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