Quantitative analysis of development and aging of genital corpuscles in glans penis of the rat
| Autor: | Kunio Murakami, Tomokazu Kawashima, Mizuho Shiino, Fumi Sato, Kiyoshi Kishi, Youichi Ishikawa, Masaaki Takayanagi, Hideo Hoshi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Calcitonin Gene-Related Peptide Vasoactive intestinal peptide Embryonic Development Substance P Biology chemistry.chemical_compound Internal medicine medicine Sexual maturity Animals Humans Sex organ Neuropeptide Y Sexual Maturation Receptor Glans penis Cell Biology General Medicine Neuropeptide Y receptor Rats Endocrinology medicine.anatomical_structure chemistry Calcitonin hormones hormone substitutes and hormone antagonists Developmental Biology Penis Vasoactive Intestinal Peptide |
| Zdroj: | Tissuecell. 47(1) |
| ISSN: | 1532-3072 |
| Popis: | The aim of the present postnatal developmental study was to determine densities of unique genital corpuscles (GCs) in glans penis of developing and aged rats. GCs were identified as corpuscular endings consisting of highly branched and coiled axons with many varicosities, which were immunoreactive for protein gene product 9.5. In addition, GCs were immunoreactive for calcitonin gene-related peptide and substance P, but not for vasoactive intestinal polypeptide and neuropeptide Y. GCs were not found in the glans penis of 1 week old rats. Densities of GCs were low at 3 weeks, significantly increased at 5 and 10 weeks, reached the peak of density at 40 weeks, and tended to decrease at 70 and 100 weeks. Sizes of GCs were small in 3 weeks old rats, increased at 5 and 10 weeks, reached the peak-size at 40 weeks and reduced in size at 70 and 100 weeks. Considering sexual maturation of the rat, the results reveal that GCs of the rat begins to develop postnatal and reaches to the peak of their development after puberty and continues to exist until old age, in contrast to prenatal and early postnatal development of other sensory receptors of glabrous skin. |
| Databáze: | OpenAIRE |
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