Role of nitric oxide in modulating neurotransmitter release from rat striatum
| Autor: | Balázs Lendvai, Attila Pliskas, N.T. Sándor, Attila Brassai |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Dopamine Pharmacology Arginine Nitric Oxide Receptors N-Methyl-D-Aspartate Nitric oxide chemistry.chemical_compound medicine Animals Rats Wistar Neurotransmitter biology General Neuroscience Dopaminergic Glutamate receptor Acetylcholine Corpus Striatum Electric Stimulation Rats Nitric oxide synthase NG-Nitroarginine Methyl Ester Biochemistry chemistry biology.protein NMDA receptor Dizocilpine Maleate medicine.drug |
| Zdroj: | Brain research bulletin. 36(5) |
| ISSN: | 0361-9230 |
| Popis: | The effect of the nitric oxide synthase inhibitor N-nitro-l-arginine methyl ester (L-NAME) on the basal and stimulation-evoked release of dopamine (DA) and acetylcholine (ACh) was investigated in rat striatum. The experiments were carried out in isolated superfused striatal slices, loaded with either [3H]-dopamine or [3H]-choline. We have found that L-NAME reduced the elecrical field stimulation-evoked release of DA, while its enantiomer N-nitro-D-arginine methyl ester (D-NAME) was ineffective. In the presence of the nitric oxide (NO) precursor l-arginine L-NAME failed to influence DA release. Furthermore, treatment with the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 completely reversed the effect of L-NAME on striatal DA release. In contrast, L-NAME had no effect on either the basal or the stimulation-evoked ACh release in any experimental conditions studied. Our data indicate that endogenously produced NO is involved in the modulation of striatal DA, but not in ACh release. Furthermore, it seems likely that the modulatory effect of NO is linked to activation of presynaptic NMDA receptors located on the striatal dopaminergic nerve terminals. |
| Databáze: | OpenAIRE |
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