Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults
| Autor: | Maria-Ioanna Christodoulou, Anna Koumarianou, Theodoros Piperos, Dimitrios Vlachodimitropoulos, Panagiota Oikonomopoulou, Margarita Baka, Kakoulis Theodoulou, Theodoros Mariolis-Sapsakos, Stylianos Argentos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Medulloblastoma medicine.medical_specialty Pediatrics Chemotherapy Oncogene business.industry medicine.medical_treatment Astrocytoma Case Report Disease medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Internal medicine Neuroblastoma medicine Stage (cooking) Rhabdomyosarcoma business neoplasms |
| Zdroj: | Case Reports in Oncological Medicine, Vol 2013 (2013) Case Reports in Oncological Medicine |
| ISSN: | 2090-6714 2090-6706 |
| Popis: | MYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms’ tumor, and small cell lung cancer. While neuroblastoma is one of the most common childhood malignancies, in adults it is extremely rare and its treatment is based on pediatric protocols that take into consideration stage and genotypic features, such as MYCN amplification. Although neuroblastoma therapy has evolved, identification of early stage patients who need chemotherapy continues to pose a therapeutic challenge. The emerging prognostic role of MYCN phenotype of this disease is currently under investigation as it may redefine MYCN amplified subgroups. We describe an unusual case of adult neuroblastoma with MYCN amplification diagnosed incidentally and discuss possible therapeutic dilemmas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text