The influence of the Ebola outbreak on presumptive and active tuberculosis in Bombali District, Sierra Leone
| Autor: | Philip Owiti, Anthony D. Harries, O M Bah, J Katta, M I Kamara, L Foray, P. Bhat, H B Kamara, B O Kamara |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Tuberculosis business.industry viruses Health Policy Treatment outcome Public Health Environmental and Occupational Health virus diseases Outbreak Retrospective cohort study Original Articles 030204 cardiovascular system & hematology Active tuberculosis medicine.disease Antiretroviral therapy Sierra leone 03 medical and health sciences 0302 clinical medicine Treatment success Internal medicine Medicine 030212 general & internal medicine business |
| Zdroj: | Public Health Action. 7:3-9 |
| ISSN: | 2220-8372 |
| DOI: | 10.5588/pha.16.0093 |
| Popis: | Setting: Bombali District, rural Sierra Leone. Objective: To compare the number of patients with presumptive tuberculosis (TB), the number of patients registered with TB (including testing for the human immunodeficiency virus [HIV] and initiation on antiretroviral therapy [ART]) and treatment outcomes during the pre-Ebola, Ebola and post-Ebola disease outbreak periods between 2013 and 2016. Design: This was a cross-sectional study and retrospective cohort analysis of treatment outcomes. Results: The mean monthly number of patients with presumptive TB before, during and post-Ebola was respectively 169, 145 and 210. The mean monthly number of registered TB cases was respectively 57, 57 and 96. Smear-positive TB was the most frequent type of TB, at 75%, 66% and 77%. The proportion of TB patients tested for HIV was 82% pre-Ebola, 74% Ebola and 99% post-Ebola. The proportion of HIV-positive patients with TB initiated on ART was respectively 46%, 85% and 100%. Treatment success among TB patients was 71% in the pre-Ebola period and 89% in the Ebola period (P < 0.001). Conclusion: During the Ebola outbreak, there were decreases in the number of presumptive TB patients and in the proportions of patients diagnosed with smear-positive TB and tested for HIV. The initiation of ART in HIV-infected TB patients and treatment outcomes remained acceptable. Pre-emptive actions are needed to maintain adequate control activities in future outbreaks. |
| Databáze: | OpenAIRE |
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