Anti-Apoptotic and Anti-Inflammatory Role of Trans ε-Viniferin in a Neuron–Glia Co-Culture Cellular Model of Parkinson’s Disease
| Autor: | Alex Gélinas, Domenico Sergi, Emilie Tardif-Pellerin, Justine Renaud, Maria-Grazia Martinoli, Jérôme Guillard, Jimmy Beaulieu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
trans-ε-viniferin
Health (social science) Parkinson's disease Inflammation Viniferin Plant Science Resveratrol Pharmacology resveratrol lcsh:Chemical technology Health Professions (miscellaneous) Microbiology Neuroprotection Article NO neuroinflammation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dopaminergic Cell apotosis medicine oxidative stress trans-epsilon-viniferin lcsh:TP1-1185 neuroprotection dopamine Cytotoxicity Neuroinflammation 030304 developmental biology 0303 health sciences Microglia food and beverages 3. Good health medicine.anatomical_structure chemistry nervous system Parkinson’s disease medicine.symptom 030217 neurology & neurosurgery Food Science |
| Zdroj: | Foods Foods, Vol 10, Iss 586, p 586 (2021) Volume 10 Issue 3 |
| ISSN: | 2304-8158 |
| Popis: | The polyphenol trans-ε-viniferin (viniferin) is a dimer of resveratrol, reported to hold antioxidant and anti-inflammatory properties. The aims of our study were to evaluate the neuroprotective potential of viniferin in the nerve growth factor (NGF)-differentiated PC12 cells, a dopaminergic cellular model of Parkinson’s disease (PD) and assess its anti-inflammatory properties in a N9 microglia–neuronal PC12 cell co-culture system. The neuronal cells were pre-treated with viniferin, resveratrol or their mixture before the administration of 6-hydroxydopamine (6-OHDA), recognized to induce parkinsonism in rats. Furthermore, N9 microglia cells, in a co-culture system with neuronal PC12, were pre-treated with viniferin, resveratrol or their mixture to investigate whether these polyphenols could reduce lipopolysaccharide (LPS)-induced inflammation. Our results show that viniferin as well as a mixture of viniferin and resveratrol protects neuronal dopaminergic cells from 6-OHDA-induced cytotoxicity and apoptosis. Furthermore, when viniferin, resveratrol or their mixture was used to pre-treat microglia cells in our co-culture system, they reduced neuronal cytotoxicity induced by glial activation. Altogether, our data highlight a novel role for viniferin as a neuroprotective and anti-inflammatory molecule in a dopaminergic cellular model, paving the way for nutraceutical therapeutic avenues in the complementary treatments of PD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|