Iron deficiency in heart failure
| Autor: | Carlo Lombardi, Stephan von Haehling, Nicolò Dasseni, Marco Metra, Elisabetta Dinatolo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Anemia Heart Failure Anemia Comorbidity 030204 cardiovascular system & hematology Ferric Compounds law.invention 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic Quality of life Randomized controlled trial law Internal medicine medicine Humans 030212 general & internal medicine Maltose Randomized Controlled Trials as Topic Heart Failure Anemia Iron-Deficiency biology business.industry General Medicine Iron deficiency medicine.disease 3. Good health Ferritin Heart failure Quality of Life biology.protein Administration Intravenous Hemoglobin Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Medicine. 19:706-716 |
| ISSN: | 1558-2027 |
| Popis: | Due to aging of the patients with heart failure, comorbidities are an emerging problem and, among them, iron deficiency is an important therapeutic target, independently of concomitant hemoglobin level. Iron deficiency affects up to 50% of heart failure patients, and it has been largely established its association with poor quality of life, impaired exercise tolerance and higher mortality. Randomized controlled trials (RCTs) and meta-analyses have demonstrated that intravenous iron supplementation in heart failure patients with iron deficiency positively affects symptoms, quality of life, exercise tolerance (as measured by VO2 peak and 6MWT), with a global trend to reduction of hospitalization rates. Current European Society of Cardiology Guidelines for heart failure recommend a diagnostic work-up for iron deficiency in all heart failure patients and intravenous iron supplementation with ferric carboxymaltose for symptomatic patients with iron deficiency, defined by ferritin level less than 100 μg/l or by ferritin 100-300 μg/l with TSAT less than 20%. On-going studies will provide new evidence for a better treatment of this important comorbidity of heart failure patients. |
| Databáze: | OpenAIRE |
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