Long non-coding RNAs as monitoring tools and therapeutic targets in breast cancer
| Autor: | Javier Salvador-Bofill, Mª Luisa Pecero, Sonia Molina-Pinelo |
|---|---|
| Přispěvatelé: | Junta de Andalucía |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Endocrine therapy Cancer Research medicine.medical_treatment Breast Neoplasms Computational biology Disease Biology ENCODE Targeted therapy 03 medical and health sciences 0302 clinical medicine Breast cancer Biomarkers Tumor medicine Humans Chemotherapy Molecular Targeted Therapy LncRNAs Regulation of gene expression Radiotherapy General Medicine medicine.disease Radiation therapy 030104 developmental biology Oncology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Molecular Medicine Female RNA Long Noncoding Human genome Function (biology) |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | [Background] Current therapeutic strategies that are used to combat breast cancer vary widely and largely depend on its clinicopathological features, including tumor subtype, size, stage, lymph node involvement, the presence of hormone receptors and/or HER2, as well as the degree of proliferative activity. Recent work has focused on improving our knowledge on the molecular mechanisms that underlie this complex disease. Most of the human genome is transcribed into RNAs that do not encode proteins. These noncoding RNAs may act as mediators in the regulation of gene expression. Based on their size and function, noncoding RNAs are classified into small noncoding RNAs (sncRNAs) and long noncoding RNAs (lncRNAs). LncRNAs have been found to play key roles in relevant biological processes, including breast cancer. As such, lncRNAs have been proposed as diagnostic and prognostic biomarkers, as predictive biomarkers and as putative therapeutic targets. [Conclusions] In this review, we discuss the potential application of lncRNAs for the monitoring and treatment of breast cancer. We conclude that lncRNAs play important roles in the pathophysiology of this disease and may serve as putative therapeutic targets. As such, tumor-specific lncRNAs may be instrumental for improving current breast cancer clinical practices. SMP was supported by the Consejería de Salud y Bienestar Social of Junta de Andalucía through the “‘Nicolás Monardes’” program [C-0040-2016]. |
| Databáze: | OpenAIRE |
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