Theophylline and ethylenediamine pharmacokinetics following administration of aminophylline to septic patients with multiorgan failure
| Autor: | L. Heslet, M. Hansen, N. A. Klitgaard, Palle Toft |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Metabolic Clearance Rate medicine.drug_class Multiple Organ Failure Ethylenediamine Critical Care and Intensive Care Medicine chemistry.chemical_compound Therapeutic index Theophylline Pharmacokinetics Sepsis Bronchodilator Humans Medicine Infusions Intravenous Aged Volume of distribution business.industry Half-life Middle Aged Ethylenediamines Aminophylline Anti-Bacterial Agents chemistry Anesthesia Female business Half-Life medicine.drug |
| Zdroj: | Intensive Care Medicine. 17:465-468 |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/bf01690768 |
| Popis: | The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4 mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ranging from 10-66% of the value obtained in healthy volunteers. The median t 1/2 beta was 18.8 h (range 5.8-25.5) compared to a normal value of 6 h. The median clearance of ethylenediamine was 54% of the normal value, while the peripheral volume of distribution was increased to 650%. Due to this t 1/2 beta was 2.3 (2.0-2.7) h, which is 5 times the normal value of 0.55 h. There was no correlation between clearance of theophylline and ethylenediamine. As theophylline has a narrow therapeutic range, routine monitoring with measurements of serum theophylline is mandatory in patients with MOF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink