Relative HLA-DRB1*04 allele frequencies in five United States populations found in a hematopoietic stem cell volunteer donor registry and seven new DRB1*04 alleles
| Autor: | Lorah Perlee, Deborah S. Chen, Ting F. Tang, Rebecca Slack, Devika Wagage, Helena Pulyaeva, Bin Tu, Li Li, Jennifer Ng, Carolyn Katovich Hurley, Robert J. Hartzman |
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| Rok vydání: | 2002 |
| Předmět: |
musculoskeletal diseases
Immunology Black People Biology White People Gene Frequency immune system diseases medicine Immunology and Allergy Humans Volunteer donor Typing Registries Allele skin and connective tissue diseases Allele frequency Alleles Genetics Asian Hla drb1 04 Pcr ssop Hematopoietic stem cell General Medicine HLA-DR Antigens Hispanic or Latino Hematopoietic Stem Cells Tissue Donors United States medicine.anatomical_structure Indians North American Pacific islanders HLA-DRB1 Chains |
| Zdroj: | Human immunology. 63(8) |
| ISSN: | 0198-8859 |
| Popis: | The frequencies of 29 HLA-DRB1*04 alleles were determined for five major U.S. populations found within a hematopoietic stem cell volunteer donor registry. One hundred sixty-one DRB1*04 positive individuals from each of the self-described groups, Caucasians, African-Americans, Asian/Pacific Islanders, Hispanics, and Native Americans, were randomly chosen from a database of 82,979 unrelated persons. Subjected to polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) typing, these 805 individuals carried a total of ten different DRB1*04 alleles, ranging from DRB1*0401 to DRB1*0411 with DRB1*0409 conspicuously absent from all five groups. The distribution of DRB1*04 alleles varied among the groups, with DRB1*0401 being predominant in Caucasians, African-Americans, and Native Americans. DRB1*0404 and DRB1*0407 were the two most commonly observed alleles in Hispanics, whereas DRB1*0405 and DRB1*04031 were most common in Asian/Pacific Islanders. The remaining 18 DRB1*04 alleles known at the time of the study were not observed. Although not observed in the frequency study, seven previously unreported DRB1*04 alleles are also described. |
| Databáze: | OpenAIRE |
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