Plasma Brain-Derived Neurotrophic Factor Levels Predict the Clinical Outcome of Depression Treatment in a Naturalistic Study

Autor: Satoshi Nishino, Tadahiro Sato, Yukio Numata, Maiko Kato, Masatake Kurita
Rok vydání: 2012
Předmět:
Male
Oncology
Anatomy and Physiology
Epidemiology
lcsh:Medicine
Neurotrophic factors
Blood plasma
Pathology
Prospective Studies
Young adult
lcsh:Science
Depression (differential diagnoses)
Aged
80 and over
Psychiatry
Multidisciplinary
Remission Induction
Middle Aged
Prognosis
Mental Health
Medicine
Major depressive disorder
Female
Research Article
Adult
medicine.medical_specialty
Adolescent
Clinical Research Design
Endocrine System
Neuropsychiatric Disorders
Biology
Young Adult
Refractory
Diagnostic Medicine
Growth Factors
Internal medicine
medicine
Humans
Aged
Psychiatric Status Rating Scales
Brain-derived neurotrophic factor
Depressive Disorder
Major
Endocrine Physiology
Brain-Derived Neurotrophic Factor
lcsh:R
medicine.disease
Clinical trial
Biomarker Epidemiology
lcsh:Q
Biomarkers
General Pathology
Zdroj: PLoS ONE
PLoS ONE, Vol 7, Iss 6, p e39212 (2012)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0039212
Popis: UNLABELLED: Remission is the primary goal of treatment for major depressive disorder (MDD). However, some patients do not respond to treatment. The main purpose of this study was to determine whether brain-derived neurotrophic factor (BDNF) levels are correlated with treatment outcomes. In a naturalistic study, we assessed whether plasma BDNF levels were correlated with clinical outcomes by measuring plasma BDNF in patients with depressive syndrome (MADRS score ≥ 18), and subsequently comparing levels between the subgroup of patients who underwent remission (MADRS score ≤ 8) and the subgroup who were refractory to treatment (non-responders). Patients with depressive syndrome who underwent remission had significantly higher plasma BDNF levels (p
Databáze: OpenAIRE
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