Breast fine-needle aspirates with scant cellularity are clinically useful
| Autor: | Jess Campagna, Waldemar A. Schmidt, Debra Robbins, Richard L. Shih, Rodney F. Pommier, John T. Vetto |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Breast biopsy medicine.medical_specialty Pathology Adolescent Breast imaging Biopsy Fine-Needle Breast Neoplasms Malignancy medicine Humans False Positive Reactions Prospective Studies skin and connective tissue diseases False Negative Reactions Aged Aged 80 and over Triple test score Suspicious for Malignancy medicine.diagnostic_test business.industry Breast lumps General Medicine Middle Aged medicine.disease Fine-needle aspiration Cytopathology Female Surgery Radiology medicine.symptom business |
| Zdroj: | The American Journal of Surgery. 189:621-626 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2005.01.040 |
| Popis: | Introduction Fine-needle aspirates (FNAs) with scant cellularity are considered inadequate by current cytopathology standards. We hypothesized that such aspirates are clinically useful. Methods A 10-year database of palpable breast lumps evaluated by FNA-based triple test (TT; FNA, breast imaging studies, and clinical breast examination) and triple test scores (TTSs; 3–9) was examined to identify FNAs with scant cellularity but without evidence of malignancy (negative SC-FNAs). These FNAs were correlated with the occurrence of any subsequent cancers (false-negative SC-FNAs) and with TTSs. Results Among a total of 324 negative SC-FNAs, 9 cancers were subsequently found at sampled sites. Seven were associated with a suspicious or malignant TTS (scores of 5 or greater) and therefore still correctly diagnosed as malignant or suspicious for malignancy. The remaining two cancers were missed by both SC-FNA and TTS (false-negative rate for TTS of 0.6%); both had scores of 4 because of suspicious imaging. Conclusions Scantly cellular but negative FNAs are useful (can avoid unnecessary invasive breast biopsy) in the evaluation of palpable breast masses, especially when interpreted in the context of the TT and TTS. |
| Databáze: | OpenAIRE |
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