Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)
Autor: | Julien Poissy, Erika Parmentier-Decrucq, Alexandre Gaudet, Mouhamed Moussa, André Vincentelli, Thibault Duburcq, Nicolas Dognon, Lille Intensive Care Covid-Group, Sylvain Normandin |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_treatment
Acute respiratory distress Pulmonary compliance Article ventilator-associated pneumonia Extracorporeal membrane oxygenation Medicine Stage (cooking) respiratory drive Lung Respiratory distress business.industry Ventilator-associated pneumonia COVID 2019 General Medicine extracorporeal membrane oxygenation acute respiratory distress syndrome medicine.disease medicine.anatomical_structure surgical procedures operative outbreak waves Anesthesia Breathing business |
Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 4839, p 4839 (2021) Journal of Clinical Medicine Volume 10 Issue 21 |
ISSN: | 2077-0383 |
Popis: | We aimed to compare the outcomes of patients under veno-venous extracorporeal membrane oxygenation (V-V ECMO) for COVID-19-Acute Respiratory Distress Syndrome (CARDS) between the first and the second wave. From 1 March 2020 to 30 November 2020, fifty patients requiring a V-V ECMO support for CARDS were included. Patient demographics, pre-ECMO, and day one, three, and seven on-ECMO data and outcomes were collected. The 90-day mortality was 11% higher during the second wave (18/26 (69%)) compared to the first wave (14/24 (58%) (p = 0.423). During the second wave, all of the patients were given steroids compared to 16.7% during the first wave (p < 0.001). The second wave’s patients had been on non-invasive ventilation support for a longer period than in the first wave, with the median time from ICU admission to ECMO implantation being significantly higher (14 (11–20) vs. 7.7 (5–12) days p < 0.001). Mechanical properties of the lung were worsened in the second wave’s CARDS patients before ECMO implantation (median static compliance 20 (16–26) vs. 29 (25–37) mL/cmH2O 0.001) and during ECMO days one, three, and seven. More bacterial co-infections before implantation and under ECMO were documented in the second wave group. Despite a better evidence-driven critical care management, we depicted fewer encouraging outcomes during the second wave. |
Databáze: | OpenAIRE |
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