Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides

Autor:	John S. Shaw, Anne Cooper, Jon Winter, Ken Grime, Howard Tucker, Chris Logan, John Oldfield, Sharon McLaughlin, John G. Cumming, David Whittaker
Rok vydání:	2005
Předmět:	Receptors CCR5 Stereochemistry medicine.drug_class Chemokine receptor CCR5 Clinical Biochemistry Benzeneacetamides Pharmaceutical Science Biological Availability Carboxamide CCR5 receptor antagonist Ligands Biochemistry Sulfone chemistry.chemical_compound Chemokine receptor Inhibitory Concentration 50 Structure-Activity Relationship Piperidines Drug Discovery medicine Structure–activity relationship Animals Humans Receptor Molecular Biology biology Molecular Structure Organic Chemistry Rats chemistry Benzene derivatives CCR5 Receptor Antagonists biology.protein Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 15(22)
ISSN:	0960-894X
Popis:	SAR and DMPK studies led to the identification of substituted N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5 chemokine receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5e161fbc0793c8580ea4844843004c https://pubmed.ncbi.nlm.nih.gov/16154744 Zobrazit plný text záznamu Full Text from ScienceDirect