Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
| Autor: | Samuel Bernard, Mikael Rydén, Erik Arner, Jonas Frisén, Peter Arner, Tom Britton, Kirsty L. Spalding, Pål O. Westermark |
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| Přispěvatelé: | Karolinska Institutet [Stockholm], Institute for Theoretical Biology (ITB), Humboldt University Of Berlin, Department of Mathematics [Sweden] (KTH), Stockholm University, Department of medicine [Stockholm], Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm], Department of Cell and Molecular Biology [Uppsala], Uppsala University, Institut Camille Jordan (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Multi-scale modelling of cell dynamics : application to hematopoiesis (DRACULA), Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Camille Jordan (ICJ), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Humboldt-Universität zu Berlin, Institut Camille Jordan [Villeurbanne] (ICJ), Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2009 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipose tissue [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] Body Mass Index Muscle hypertrophy chemistry.chemical_compound 0302 clinical medicine Adipocyte Blood plasma Adipocytes Insulin MESH: Obesity MESH: Cell Size MESH: Aged 0303 health sciences MESH: Middle Aged Fasting Middle Aged Hyperplasia Adipose Tissue MESH: Young Adult Female Original Article Obesity Studies MESH: Adipose Tissue Adult medicine.medical_specialty Adolescent [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS] MESH: Fasting 030209 endocrinology & metabolism MESH: Insulin Biology MESH: Body Mass Index Young Adult 03 medical and health sciences Thinness Internal medicine Internal Medicine medicine Humans Obesity MESH: Adipocytes Aged Cell Size 030304 developmental biology MESH: Adolescent MESH: Humans MESH: Thinness MESH: Hyperplasia Body Weight MESH: Adult medicine.disease MESH: Male MESH: Body Weight Endocrinology chemistry MESH: Female Body mass index |
| Zdroj: | Diabetes Diabetes, 2010, 59 (1), pp.105-9. ⟨10.2337/db09-0942⟩ Diabetes, American Diabetes Association, 2010, 59 (1), pp.105-9. ⟨10.2337/db09-0942⟩ |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | OBJECTIVE Adipose tissue may contain few large adipocytes (hypertrophy) or many small adipocytes (hyperplasia). We investigated factors of putative importance for adipose tissue morphology. RESEARCH DESIGN AND METHODS Subcutaneous adipocyte size and total fat mass were compared in 764 subjects with BMI 18–60 kg/m2. A morphology value was defined as the difference between the measured adipocyte volume and the expected volume given by a curved-line fit for a given body fat mass and was related to insulin values. In 35 subjects, in vivo adipocyte turnover was measured by exploiting incorporation of atmospheric 14C into DNA. RESULTS Occurrence of hyperplasia (negative morphology value) or hypertrophy (positive morphology value) was independent of sex and body weight but correlated with fasting plasma insulin levels and insulin sensitivity, independent of adipocyte volume (β-coefficient = 0.3, P < 0.0001). Total adipocyte number and morphology were negatively related (r = −0.66); i.e., the total adipocyte number was greatest in pronounced hyperplasia and smallest in pronounced hypertrophy. The absolute number of new adipocytes generated each year was 70% lower (P < 0.001) in hypertrophy than in hyperplasia, and individual values for adipocyte generation and morphology were strongly related (r = 0.7, P < 0.001). The relative death rate (∼10% per year) or mean age of adipocytes (∼10 years) was not correlated with morphology. CONCLUSIONS Adipose tissue morphology correlates with insulin measures and is linked to the total adipocyte number independently of sex and body fat level. Low generation rates of adipocytes associate with adipose tissue hypertrophy, whereas high generation rates associate with adipose hyperplasia. |
| Databáze: | OpenAIRE |
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