Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes
| Autor: | Johan Herlitz, Marianne Hartford, Thomas Karlsson, Kenneth Caidahl, Hans Herlitz, Anita Persson, Elisabeth Perers |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty Disease Comorbidity 030204 cardiovascular system & hematology Plasma renin activity 03 medical and health sciences 0302 clinical medicine Internal medicine Renin medicine Humans Cardiac and Cardiovascular Systems 030212 general & internal medicine Acute Coronary Syndrome Aged Retrospective Studies Aged 80 and over Sweden Kardiologi biology business.industry Incidence (epidemiology) Incidence Hazard ratio COVID-19 Angiotensin-converting enzyme Middle Aged medicine.disease Prognosis Confidence interval Survival Rate Heart failure Cardiology biology.protein Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | International journal of cardiology. 329 |
| ISSN: | 1874-1754 |
| Popis: | BACKGROUND: Plasma renin activity (PRA) has been related to all-cause mortality and cardiovascular events in patients with cardiovascular disease. However, data from patients with acute coronary syndromes (ACS) are sparse. METHODS: Determination of PRA was made in 550 patients with ACS, including a subgroup of 287 patients not on treatment with angiotensin converting enzyme inhibitors, angiotensin receptor blockers or diuretics, and without heart failure. We evaluated the relations between PRA and all-cause mortality after three years and long-term, and to cardiovascular events after median 8.7 years. Adjustments were made for variables that influenced the hazard ratio (HR) > 5% for the relation between PRA and outcome. RESULTS: Baseline PRA was associated with all-cause mortality during three-years (unadjusted HR 1.74 per 1 SD increase in logarithmically transformed PRA; 95% confidence interval (CI) 1.39-2.16, p |
| Databáze: | OpenAIRE |
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