EEG Findings May Serve as a Potential Biomarker for Anti-NMDA Receptor Encephalitis
| Autor: | Joanna Suski, Erin P. Foff, M. Beatriz S. Lopes, Mark Quigg, David H. Taplinger |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Encephalopathy Population Electroencephalography Sensitivity and Specificity Pattern Recognition Automated 03 medical and health sciences Young Adult 0302 clinical medicine Modified Rankin Scale Internal medicine medicine Humans Diagnosis Computer-Assisted education Child Retrospective Studies Anti-NMDA receptor encephalitis Anti-N-Methyl-D-Aspartate Receptor Encephalitis education.field_of_study medicine.diagnostic_test business.industry Brain Reproducibility of Results General Medicine medicine.disease 030104 developmental biology Neurology Delta Rhythm Immunology Etiology Biomarker (medicine) Female Neurology (clinical) business Beta Rhythm 030217 neurology & neurosurgery Encephalitis Algorithms |
| Zdroj: | Clinical EEG and neuroscience. 48(1) |
| ISSN: | 2169-5202 |
| Popis: | Objective. To determine if an electroencephalographic (EEG) characteristic, beta:delta power ratio (BDPR), is significantly higher for N-methyl-d-aspartate receptor encephalitis (NMDARE) patients than for non-NMDARE patients on presenting EEG. Identification of an additional EEG biomarker with significant specificity for NMDARE (in the absence of frank delta brush) could potentially allow for early identification of at-risk patients. Methods. Single center retrospective comparison of NMDARE and non-NMDARE consecutive cases of encephalitis, collated over a 6-year period (from 2008 to 2014). Results. None of the 10 NMDARE patients displayed the extreme delta brush pattern on EEG previously described, but the ratio of BDPR was significantly higher for NMDARE patients ( P < .005). There was no significant relationship between BDPR and the time of recording from symptom onset. Additional analysis of clinical characteristics also indicated that the patients with NMDARE (median age 19.5 years) were younger than the 5 patients with non-NMDARE (median age 36 years). Encephalopathy, seizure, and psychiatric complaints were the most common diagnoses at time of first health care presentation and did not favor a single etiology, though the latter was present only in the NMDARE population (50% at T0). Prodromal illness featuring headache was more common in the non-NMDARE population. Outcomes, as measured by the Modified Rankin Scale, were globally better in the NMDARE group. Conclusions. Patients with NMDARE had a significantly higher BDPR on EEG when compared with non-NMDARE patients even in the absence of extreme delta brush. This suggests that early EEG characteristics may be helpful in distinguishing NMDARE from non-NMDARE. |
| Databáze: | OpenAIRE |
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