Effect of Selected Stilbenoids on Human Fecal Microbiota
| Autor: | Jakub Mrázek, Veronika Jarosova, Pavel Klouček, Chahrazed Mekadim, Ondrej Vesely, Jiri Killer, Petr Marsik, José Diógenes Jaimes, Jaroslav Havlik, Karel Šmejkal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmaceutical Science Faecalibacterium prausnitzii Gut flora resveratrol Analytical Chemistry stilbenoids Clostridium Feces chemistry.chemical_compound Lachnospiraceae RNA Ribosomal 16S Stilbenes Drug Discovery pinostilbene Food science fermentation Phylogeny 16S rRNA gene sequencing Piceatannol Molecular Structure biology Chemistry piceatannol Pinostilbene Chemistry (miscellaneous) Molecular Medicine Firmicutes phenolics batatasin III Article lcsh:QD241-441 03 medical and health sciences oxyresveratrol lcsh:Organic chemistry human gut microbiota human colon model Humans Physical and Theoretical Chemistry polyphenols 030109 nutrition & dietetics Bacteroidetes Organic Chemistry biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology thunalbene Metagenome Metagenomics |
| Zdroj: | Molecules Volume 24 Issue 4 Molecules, Vol 24, Iss 4, p 744 (2019) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24040744 |
| Popis: | Dietary phenolics or polyphenols are mostly metabolized by the human gut microbiota. These metabolites appear to confer the beneficial health effects attributed to phenolics. Microbial composition affects the type of metabolites produced. Reciprocally, phenolics modulate microbial composition. Understanding this relationship could be used to positively impact health by phenolic supplementation and thus create favorable colonic conditions. This study explored the effect of six stilbenoids (batatasin III, oxyresveratrol, piceatannol, pinostilbene, resveratrol, thunalbene) on the gut microbiota composition. Stilbenoids were anaerobically fermented with fecal bacteria from four donors, samples were collected at 0 and 24 h, and effects on the microbiota were assessed by 16S rRNA gene sequencing. Statistical tests identified affected microbes at three taxonomic levels. Observed microbial composition modulation by stilbenoids included a decrease in the Firmicutes to Bacteroidetes ratio, a decrease in the relative abundance of strains from the genus Clostridium, and effects on the family Lachnospiraceae. A frequently observed effect was a further decrease of the relative abundance when compared to the control. An opposite effect to the control was observed for Faecalibacterium prausnitzii, whose relative abundance increased. Observed effects were more frequently attributed to resveratrol and piceatannol, followed by thunalbene and batatasin III. |
| Databáze: | OpenAIRE |
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