Coronary artery calcification in middle-aged women with premature ovarian insufficiency

Autor: Gunning, M.N., Meun, C., Rijn, B.B. van, Maas, A.H.E.M., Benschop, L., Franx, A., Boersma, E., Budde, R.P.J., Appelman, Y., Lambalk, C.B., Eijkemans, M.J.C., Velthuis, B.K., Laven, J.S.E., Fauser, B.C.J.M., Baart, S., Brouwers, L., Budde, R., Cannegieter, S., Dam, V., Daan, N., Eijkemans, R., Fauser, B., Ferrari, M., Groot, C. de, Gunning, M., Hoek, A., Koffijberg, E., Koster, W., Kruit, M., Lagerweij, G., Lambalk, N., Laven, J., Linstra, K., Lugt, A. van der, Maas, A., Brink, A.M. van den, Middeldorp, S., Moons, K., Rijn, B. van, Lennep, J.R. van, Roos-Hesselink, J., Scheres, L., Schouw, Y. van der, Steegers, E., Steegers, R., Terwindt, G., Velthuis, B., Wermer, M., Zick, B., Zoet, G., CREW Consortium
Přispěvatelé: Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, Obstetrics & Gynecology, Cardiology, Radiology & Nuclear Medicine, Internal Medicine, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Reproduction & Development (AR&D), Obstetrics and gynaecology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, ACS - Microcirculation, Reproductive Origins of Adult Health and Disease (ROAHD), Health Technology & Services Research
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Heart disease
Endocrinology
Diabetes and Metabolism
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
UT-Hybrid-D
Primary Ovarian Insufficiency
GUIDELINES
Coronary artery disease
0302 clinical medicine
Endocrinology
reproductive disorder
Medicine
RISK
education.field_of_study
cardiovascular
POI
Calcinosis
Middle Aged
Coronary Vessels
Menopause
risk factor
CARDIOVASCULAR-DISEASE
030220 oncology & carcinogenesis
Cohort
Female
STROKE
MENOPAUSE
medicine.medical_specialty
Population
SOCIETY
030209 endocrinology & metabolism
HEART-DISEASE
PROFILE
Premature ovarian insufficiency
CALCIUM
coronary artery calcium score
03 medical and health sciences
Internal medicine
Diabetes mellitus
Humans
COMPUTED-TOMOGRAPHY
cardiovascular diseases
Risk factor
education
Aged
business.industry
nutritional and metabolic diseases
medicine.disease
22/4 OA procedure
Case-Control Studies
business
Zdroj: Clinical Endocrinology, 91, 2, pp. 314-322
Gunning, M N, Meun, C, van Rijn, B B, Maas, A H E M, Benschop, L, Franx, A, Boersma, E, Budde, R P J, Appelman, Y, Lambalk, C B, Eijkemans, M J C, Velthuis, B K, Laven, J S E, Fauser, B C J M & On behalf of the CREW-consortium 2019, ' Coronary artery calcification in middle-aged women with premature ovarian insufficiency ', Clinical Endocrinology, vol. 91, no. 2, pp. 314-322 . https://doi.org/10.1111/cen.14003
Clinical endocrinology, 91(2), 314-322. Wiley-Blackwell
Clinical Endocrinology, 91(2), 314-322. Wiley-Blackwell Publishing Ltd
Clinical Endocrinology, 91(2), 314-322. Wiley-Blackwell
Clinical Endocrinology, 91(2), 314-322. Wiley
Clinical Endocrinology, 91(2), 314-322. WILEY
Clinical Endocrinology, 91, 314-322
Clinical Endocrinology, 91(2), 314-322
ISSN: 0300-0664
DOI: 10.1111/cen.14003
Popis: Item does not contain fulltext OBJECTIVE: Women with premature ovarian insufficiency (POI) enter menopause before age 40. Early menopause was associated with increased risk for coronary artery disease (CAD), death from cardiovascular disease and all-cause mortality. We compared the prevalence of CAD between middle-aged women on average 10 years following the initial POI diagnosis, with a population-based cohort. DESIGN: Cross-sectional case-control study. PARTICIPANTS: Women from two Dutch University Medical Centers above 45 years of age previously diagnosed with POI (n = 98) were selected and compared with age- and race-matched controls from the Multi-Ethnic Study of Atherosclerosis (MESA). MEASUREMENTS: The primary outcome was detectable coronary artery calcium (CAC) determined by coronary computed tomography (CCT). RESULTS: Women with POI had significantly higher blood pressure, cholesterol and glucose, despite lower BMI compared to controls. Similar proportions of detectable CAC (CAC score >0 Agatston Units) were observed in women with POI and controls (POI n = 16 (16%), controls n = 52 (18%), P = 0.40 and Padj = 0.93). In women with POI separately, we were not able to identify associations between CVD risk factors and CAC. The following CVD risk factors in controls were positively associated with CAC: age, diabetes mellitus, hypertension and LDL cholesterol. HRT use was negatively associated with CAC in controls. CONCLUSIONS: The presence of CAC did not differ significantly in women with POI around 50 years of age, compared to an age- and race-matched control group. We observe no increased calcified coronary disease in POI patients, despite the presence of unfavourable cardiovascular risk factors in these women.
Databáze: OpenAIRE
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