Pharmacokinetics of Single-Dose Oral Pregabalin Administration in Normal Cats
| Autor: | Mark Rishniw, Michaela A Esteban, Wayne S. Schwark, Curtis W. Dewey, Dawn M. Boothe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
040301 veterinary sciences
medicine.drug_class Sedation Pregabalin 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Pharmacokinetics medicine Dosing Original Research seizures lcsh:Veterinary medicine CATS General Veterinary business.industry cats Area under the curve 04 agricultural and veterinary sciences Pharmacokinetic analysis Sedative Anesthesia lcsh:SF600-1100 epilepsy Veterinary Science pregabalin medicine.symptom business pharmacokinetics 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in Veterinary Science Frontiers in Veterinary Science, Vol 5 (2018) |
| ISSN: | 2297-1769 |
| DOI: | 10.3389/fvets.2018.00136 |
| Popis: | Objective: To describe the pharmacokinetic parameters of oral pregabalin in normal cats after single oral dosing. Animals: Six healthy adult research cats. Procedures: Following sedation and indwelling catheter placement, one oral (4 mg/kg) dose of pregabalin was administered. Blood samples were collected at 0, 15 and 30 min and 1, 1.5, 2, 3, 4, 6, 8, 12, 24, and 36 h after administration. Plasma pregabalin concentrations were measured by high-performance liquid chromatography and subjected to pharmacokinetic analysis using commercial software. Results: Four of six cats developed moderate sedation after pregabalin administration. The peak pregabalin concentration was 8.3 ± 1.6 μg/ml which occurred at 2.9 ± 1.2 h. Elimination half-life was 10.4 ± 2.6 h and area under the curve was 133.9 ± 71.5 μg-h/ml. Time above the minimum therapeutic concentration for seizure control in dogs and people (2.8 μg/ml) was 17.6 ± 6.2 h. Using these data, predicted minimum, maximum and average steady state concentrations were calculated for 12 and 24 h dosing intervals. Conclusions and Clinical Relevance: Pregabalin (4 mg/kg) administered orally to cats results in plasma concentrations within the range considered to be efficacious for seizure control in dogs and humans between 1.5 and at least 12 h. Because of moderate sedative side effects in the majority of cats at this dose and high calculated maximum steady state concentrations, a lower dose, given more frequently (1–2 mg/kg q 12 h), should be evaluated in prospective clinical studies. |
| Databáze: | OpenAIRE |
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