Evaluation of function and structure of arterial wall in girls and young women with Turner syndrome
| Autor: | Giorgio Radetti, Mariacarolina Salerno, A. Colao, C. Di Somma, Laura Mazzanti, Donatella Capalbo, E. Gottardi, Federica Tamburrino |
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| Přispěvatelé: | Radetti, G, Mazzanti, L., Di Somma, C., Salerno, M., Gottardi, E., Capalbo, D., Tamburrino, F., Colao, A., Mazzanti, L, Di Somma, C, Salerno, Mariacarolina, Gottardi, E, Capalbo, Donatella, Tamburrino, F, Colao, Annamaria |
| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endothelium Carotid Artery Common Endocrinology Diabetes and Metabolism Carotid arteries Turner Syndrome Blood Pressure Ethinyl Estradiol Carotid Intima-Media Thickness Young Adult Endocrinology Internal medicine Turner syndrome medicine Humans Arterial wall Young adult Child Inverse correlation business.industry Endothelial function medicine.disease Intima media thickne medicine.anatomical_structure Blood pressure Intima-media thickness Function and structure arterial wall girls and young women Turner syndrome cardiovascular system Cardiology Female Endothelium Vascular business |
| Zdroj: | Journal of Endocrinological Investigation. 38:963-970 |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-015-0268-9 |
| Popis: | Patients with Turner syndrome (TS) are frequently affected by congenital as well as acquired cardiovascular diseases. The aim of the study was to evaluate the blood pressure, the endothelial function (FMD) and the intima media thickness (IMT) at the level of the common carotid arteries in a group of girls and young women with TS in comparison to healthy controls. We evaluated 40 unselected TS patients, with a mean age of 18.6 ± 0.9 years and 103 age matched healthy subjects. Main outcome measures: blood pressure, FMD and IMT. No differences were found in systolic and diastolic blood pressure between TS patients and controls. FMD was higher in TS than in controls (14.2 ± 1.4 vs 11.4 ± 0.3 %, p = 0.005) whereas IMT was not statistically different in the two study groups (0.54 ± 0.04 vs 0.57 ± 0.01 mm). However, in TS patients an inverse correlation was found between FMD and both age (−0.03 ± 0.01, p = 0.003) and years of estrogen therapy (−0.72 ± 0.31, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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