A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology
| Autor: | Erhan Turgut Tali, Aslihan Onay, Selçuk Aslan, Hale Yapici Eser, Cigdem Ulasoglu Yildiz |
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| Přispěvatelé: | Onay, Aslıhan, Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359), Ulaşoğlu-Yıldız, Çiğdem, Aslan, Selçuk, Talı, Erhan Turgut, School of Medicine, Department of Radiology, Department of Psychiatry |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Medicine Radiology Psychiatry Audiology Grey matter Brain mapping behavioral disciplines and activities White matter 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Radiology Nuclear Medicine and imaging Cerebral Cortex Brain Mapping medicine.diagnostic_test Internal capsule Functional connectivity Antipsychotic treatment Cortical thickness Negative symptoms Anterior limb Metaanalysis Abnormalities Associations Microstructure business.industry Superior longitudinal fasciculus Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging White Matter 030104 developmental biology medicine.anatomical_structure Diffusion Tensor Imaging Neuroradiology nervous system Schizophrenia Female Cardiology and Cardiovascular Medicine business Insula 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Diagnostic and Interventional Radiology |
| Popis: | PURPOSE: Grey matter and white matter changes within the brain are well defined in schizophrenia. However, most studies focused on either grey matter changes or white matter integrity separately; only in limited number of studies these changes were interpreted in the same frame. In addition, the relationship of these findings with clinical variables is not clearly established. Here, we aimed to investigate the grey matter and white matter changes in schizophrenia patients and exhibit the relation of these imaging findings with clinical variables. METHODS: A total of 20 schizophrenia patients and 16 matched healthy controls underwent magnetic resonance imaging to investigate the grey matter and white matter alterations that occur in schizophrenia patients using voxel-based morphometry (VBM) and whole brain voxel-wise analysis of diffusion tensor imaging (DTI) parameters with SPM8, respectively. While the preprocessing steps ofVBM were performed with the default parameters of VBM8 toolbox, the preprocessing steps of DTI were carried out using FSL. Additionally, VBM results were correlated with clinical variables. RESULTS: Bilateral insula showed decreased grey matter volume in schizophrenia patients compared with healthy controls (P < 0.01). The opposite contrast did not show a significant difference. Psychiatric scores, duration of illness, and age were not correlated with the decreased grey matter volume of insula in schizophrenia patients. DTI analysis revealed a significant increase in mean, radial, and axial diffusivity, mainly of the fibers of bilateral anterior thalamic radiation and superior longitudinal fasciculus with left predominance, which intersected with bilateral subinsular white matter (P < 0.05). CONCLUSION: Our findings suggest that insula may be the main affected brain region in schizophrenia, which is also well supported by the literature. Our results were independent of disease duration and schizophrenia symptoms. White matter alterations were observed within bilateral anterior thalamic radiation and superior longitudinal fasciculus that intersects with subinsular white matter. Studies with larger sample sizes and more detailed clinical assessments are required to understand the function of insula in the neurobiology of schizophrenia. NA |
| Databáze: | OpenAIRE |
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