Effects of Citri Reticulatae Pericarpium and grapefruit juice on the pharmacokinetics of omeprazole in rats
| Autor: | Wenge Huang, Hong Li, Yi-Ping Yu, Ping Wang, Yan Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Naringenin
food.ingredient 030309 nutrition & dietetics Biophysics Decoction Pharmacology Grapefruit juice Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Hesperidin 0404 agricultural biotechnology food Pharmacokinetics Citrus paradisi medicine Animals Chromatography High Pressure Liquid Omeprazole 0303 health sciences Chemistry food and beverages 04 agricultural and veterinary sciences Cell Biology 040401 food science Rats Bioavailability Fruit and Vegetable Juices Food Science medicine.drug |
| Zdroj: | Journal of Food Biochemistry. 46 |
| ISSN: | 1745-4514 0145-8884 |
| DOI: | 10.1111/jfbc.13804 |
| Popis: | The effects of Citri Reticulatae Pericarpium (CRP) and grapefruit juice (GFJ) on the pharmacokinetics of omeprazole were investigated in this study. Sprague-Dawley rats were pretreated with CRP decoction or GFJ for 28 consecutive days. After a single intragastric administration of 6.0 mg/kg, the concentration of omeprazole in the plasma was determined by high-performance liquid chromatography (HPLC), and the pharmacokinetic parameters were calculated by Kinetica software 5.0. A high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was established to identify the chemical components in CRP decoction and GFJ. The results showed that the AUCt -∞ was significantly increased when coadministrated with CRP. The AUC0- t and AUC0-∞ was remarkably increased; the Cl was decreased when coadministrated with GFJ. A total of 31 and 28 bioactive compounds were identified in the CRP decoction and GFJ, respectively. Flavonoids and furanocoumarins, including hesperidin, hesperetin, naringenin, sinensetin, tangeretin, nobiletin, and 6',7'-dihydroxybergamottin, were simultaneously identified in CRP decoction and GFJ. This study indicates that the increased bioavailability of omeprazole may be due to the inhibition of hepatic cytochrome P450 enzymes, and the systemic exposure should be monitored when concomitant administration with CRP and GFJ. PRACTICAL APPLICATIONS: Citri Reticulatae Pericarpium (CRP) has been widely consumed as a daily condiment, functional food, and a traditional Chinese medicine. Omeprazole, primary metabolized by CYP450 enzymes, was usually coadministered with CRP for the treatment of gastrointestinal disease. Studies have confirmed that much fruit juices, including grapefruit juice, may affect drug metabolism enzymes. CRP and grapefruit (Citrus paradisi Macf.) belong to the genus Citrus and family Rutaceae with different species. Therefore, the pharmacokinetic interaction of CRP decoction and grapefruit juice with omeprazole is worthy of attention. The results of this study can provide basic pharmacological data support for the safe and effective clinical use of omeprazole. It can also provide a theoretical basis for the development of new functional products and daily application of CRP. |
| Databáze: | OpenAIRE |
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