Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
| Autor: | Giuliana Guggino, Chiara Rizzo, Lidia La Barbera, Serena Fasano, Giulia Grasso, C. Schinocca, Francesco Ciccia |
|---|---|
| Přispěvatelé: | Schinocca C., Rizzo C., Fasano S., Grasso G., La Barbera L., Ciccia F., Guggino G., Schinocca, C., Rizzo, C., Fasano, S., Grasso, G., La Barbera, L., Ciccia, F., Guggino, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine medicine.medical_treatment Immunology inflammatory diseases Inflammation autoimmune disease Autoimmunity Review Inflammatory bowel disease Interleukin-23 Th17 Cell Rheumatic Disease 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Immune system IL-23 Psoriasis Rheumatic Diseases Interleukin 23 medicine Animals Humans Immunology and Allergy autoimmune diseases Molecular Targeted Therapy IL-23/IL-17 axi 030203 arthritis & rheumatology business.industry IL-23/IL-17 axis Animal Interleukin-17 medicine.disease inflammatory disease IL-17 030104 developmental biology Cytokine Th17 Cells Interleukin 17 medicine.symptom lcsh:RC581-607 business Human |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| Popis: | Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation and activation of T helper 17 (Th17) cells with subsequent production of IL-17A, IL-17F, IL-6, IL-22, and tumor necrosis factor α (TNF-α). Although IL-23 plays a pivotal role in the protective immune response to bacterial and fungal infections, its dysregulation has been shown to exacerbate chronic immune-mediated inflammation. Well-established experimental data support the concept that IL-23/IL-17 axis activation contributes to the development of several inflammatory diseases, such as PsA, Psoriasis, Psoriatic Arthritis; AS, Ankylosing Spondylitis; IBD, Inflammatory Bowel Disease; RA, Rheumatoid Arthritis; SS, Sjogren Syndrome; MS, Multiple Sclerosis. As a result, emerging clinical studies have focused on the blockade of this pathogenic axis as a promising therapeutic target in several autoimmune disorders; nevertheless, a greater understanding of its contribution still requires further investigation. This review aims to elucidate the most recent studies and literature data on the pathogenetic role of IL-23 and Th17 cells in inflammatory rheumatic diseases. |
| Databáze: | OpenAIRE |
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