Epidemiologic and mucosal immunologic aspects of HPV infection and HPV-related cervical neoplasia in the lower female genital tract
| Autor: | J. Ter Schegget, Matthé P.M. Burger, Ming Y. Tjiong, T. A. Out, N. van der Vange |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Urogenital System
Uterine Cervical Neoplasms HPV vaccines Immune system medicine Disease Transmission Infectious Humans Developing Countries Papillomaviridae Cervical cancer Mucous Membrane Transmission (medicine) business.industry Incidence Papillomavirus Infections HPV infection Obstetrics and Gynecology virus diseases Viral Vaccines medicine.disease Vaccination Tumor Virus Infections Oncology Mucosal immunology Immunology Humoral immunity Female business |
| Zdroj: | Tjiong, M Y, Out, T A, Ter Schegget, J, Burger, M P M & Van Der Vange, N 2001, ' Epidemiologic and mucosal immunologic aspects of HPV infection and HPV-related cervical neoplasia in the lower female genital tract : A review ', International Journal of Gynecological Cancer, vol. 11, no. 1, pp. 9-17 . https://doi.org/10.1046/j.1525-1438.2001.011001009.x |
| ISSN: | 1048-891X |
| DOI: | 10.1046/j.1525-1438.2001.011001009.x |
| Popis: | Human papillomavirus (HPV) infections are known to play an important role in the pathogenesis of cervical neoplasia. Considering the morbidity and mortality of cervical cancer, infection with HPV can be regarded as a worldwide problem, especially in developing countries. Currently, many studies focus on the development of both prophylactic and therapeutic HPV vaccines. Crucial for these vaccination protocols to be successful is that they will result in a long-lasting ability to generate an immune response that will eliminate the virus. HPV transmission and subsequent infection is a local event in the lower female genital tract and therefore the efficacy of vaccines against this locally transmitted infection can be best assessed by parameters of local immunity. In this review we describe both the epidemiology of HPV-related cervical neoplasia and the general aspects of mucosal immunity in the female genital tract while focusing on the local humoral immunity in HPV-related cervical neoplasia. |
| Databáze: | OpenAIRE |
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