Hematogones With Lambda Light Chain Restriction in a 4-Year-Old Boy With Burkitt Lymphoma: A Potential Diagnostic Pitfall
| Autor: | Tesha Guillory, Daniel John Bergsagel, Elizabeth P Weinzierl, Silvia T. Bunting, Shiyong Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Clinical Biochemistry Population Cell Separation Biology Immunoglobulin light chain 03 medical and health sciences 0302 clinical medicine Immunophenotyping Case Studies Immunoglobulin lambda-Chains Antigens CD hematogones medicine Humans Diagnostic Errors education light-chain restriction B cell education.field_of_study B-Lymphocytes Cluster of differentiation lymphoproliferative disorders flow cytometry Precursor Cells B-Lymphoid Biochemistry (medical) hematopathology Gene rearrangement Lambda light chain medicine.disease Burkitt Lymphoma medicine.anatomical_structure 030220 oncology & carcinogenesis Child Preschool Immunoglobulin Light Chains Bone marrow Burkitt's lymphoma 030215 immunology |
| Zdroj: | Laboratory Medicine |
| ISSN: | 1943-7730 0007-5027 |
| Popis: | Hematogones are immature normal B cell precursors with a characteristic immunophenotype profile on flow cytometry that typically do not express surface immunoglobulin light chains. In this report, we describe a case in which the hematogones exhibit light chain restriction. Our patient was a 4-year-old boy with a complicated medical history involving treatment for a presumed bilateral Wilms tumor of the kidney that on later resection was diagnosed as Burkitt lymphoma. Flow cytometry analysis of his bone marrow revealed a small distinct population of cells expressing dim cluster of differentiation (CD)10, CD19, CD22, CD38, dim CD58, human leukocyte antigen-D related (HLA-DR), and dim CD45, which are characteristic of hematogones. These cells, however, demonstrated dim surface immunoglobulin lambda light-chain restriction. Molecular study results for immunoglobulin heavy and kappa light-chain gene rearrangements were negative. We present this case to raise awareness of the potential pitfalls of working up bone marrow for involvement by B cell lymphoproliferative disorder. |
| Databáze: | OpenAIRE |
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