The sigma receptor ligand SR 31742A increases neurotensin in the nucleus accumbens but not in the caudate-putamen of the rat
| Autor: | Philippe Soubrie, Peter Keane, C Labie, Gérard Le Fur |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Sigma receptor Caudate nucleus Neuropeptide Nucleus accumbens Nucleus Accumbens Rats Sprague-Dawley chemistry.chemical_compound Limbic system Internal medicine Haloperidol medicine Animals Neurotensin Pharmacology Dose-Response Relationship Drug Chemistry Putamen Azepines Rats medicine.anatomical_structure Endocrinology nervous system Caudate Nucleus Injections Intraperitoneal medicine.drug Antipsychotic Agents |
| Zdroj: | European journal of pharmacology. 231(3) |
| ISSN: | 0014-2999 |
| Popis: | The effects of SR 31742A, a specific σ site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system. |
| Databáze: | OpenAIRE |
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