The interpretive contribution of the baseline serum cortisol concentration of the ACTH stimulation test in the diagnosis of pituitary dependent hyperadrenocorticism in dogs
| Autor: | Sharon Kuzi, Ella Ariel, Kent R. Refsal, Ran Nivy, E. Yas-Natan, Michal Mazaki-Tovi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Adrenocortical Hyperfunction Optimal cutoff Hydrocortisone 040301 veterinary sciences Standard Article Gastroenterology 0403 veterinary science 03 medical and health sciences Endocrinology Dogs Adrenocorticotropic Hormone Reference Values Internal medicine basal medicine Animals Dog Diseases General Veterinary Receiver operating characteristic medicine.diagnostic_test business.industry added‐value post‐stimulation ACTH stimulation test 04 agricultural and veterinary sciences Standard Articles Confidence interval 030104 developmental biology SMALL ANIMAL Cushing's business Area under the roc curve Serum cortisol |
| Zdroj: | Journal of Veterinary Internal Medicine |
| ISSN: | 0891-6640 |
| DOI: | 10.1111/jvim.15330 |
| Popis: | BACKGROUND: Current recommendation for performing the ACTH stimulation test (ACTHST) for diagnosis of hyperadrenocorticism (HAC) advocates the collection of baseline serum cortisol concentration (BC), but no references for interpretation of its results exist. OBJECTIVE: Evaluate the contribution of BC of the ACTHST to the diagnosis of HAC. ANIMALS: Fifty‐four dogs were evaluated for suspected HAC at a referral hospital. METHODS: Records of dogs that had been evaluated by ACTHST for suspected HAC were reviewed. Receiver operator characteristics (ROC) analyses were used to assess the performance of BC, post‐stimulation serum cortisol concentrations (PC), post‐to‐baseline cortisol concentration difference (DeltaC) and quotient (RatioC) for the diagnosis of HAC by comparing the area under the ROC curve (AUC) of PC to each of the other tests. RESULTS: The AUC of PC (95% confidence interval [CI]: 0.92; 95% CI, 0.81‐0.98) was significantly higher than AUCs of BC (0.70; 95% CI, 0.56‐0.82; P = .01) and RatioC (0.55; 95% CI, 0.41‐0.69; P |
| Databáze: | OpenAIRE |
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