Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
| Autor: | Jochen Huehn, Uta Haubold, Uwe Niesner, Alf Hamann, Grzegorz K. Przybylski, Alexander Scheffold, Rolf Bräuer, Christiane Siewert, Joerg Lauber, Gudrun F. Debes, Kerstin Siegmund, Joachim C. U. Lehmann, Christian Schmidt, Markus Feuerer, Jan Buer, Maurus de la Rosa, Oliver Frey |
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| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Chemokine Immunology Integrin chemokines Inflammation Biology Article Immunophenotyping Mice Interleukin 21 Antigen T-Lymphocyte Subsets medicine Animals Immunology and Allergy lymphocyte migration IL-2 receptor CD25 Oligonucleotide Array Sequence Analysis Mice Inbred BALB C Reverse Transcriptase Polymerase Chain Reaction Effector Receptors Interleukin-2 Arthritis Experimental Cell biology Mice Inbred C57BL CD4 Antigens CD103 biology.protein medicine.symptom Immunologic Memory |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis. |
| Databáze: | OpenAIRE |
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