A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels
Autor: | Ph. Colombat, Lotfi Benboubker, C. Valat, M. Delain, J. P. Lamagnere, Fetissof F, Guillaume Cartron, T. Lefranq, Claude Linassier, M. Bout |
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Rok vydání: | 2000 |
Předmět: |
Adult
Male Prognostic factor medicine.medical_specialty Pathology Multivariate analysis Severity of Illness Index Gastroenterology Disease-Free Survival Serology Internal medicine Biomarkers Tumor medicine Overall survival Humans Life Tables Aged Neoplasm Staging L-Lactate Dehydrogenase business.industry Lymphoma Non-Hodgkin Remission Induction Complete remission Hematology Middle Aged Prognosis medicine.disease Survival Analysis Neoplasm Proteins Lymphoma Non-Hodgkin's lymphoma Treatment Outcome Oncology CA-125 Antigen Serum ca125 Female beta 2-Microglobulin business Follow-Up Studies |
Zdroj: | Scopus-Elsevier |
ISSN: | 0923-7534 |
Popis: | Summary Background: Serum CA125 (sCA125) was recently reported to be of clinical value in the staging and follow-up of patients with non-Hodgkin's lymphoma (NHL). This report aims to investigate the prognostic value of a new serologic index combining sCA125 and LDH serum levels. Patients and methods: One hundred thirty-seven patients were studied, sixty-three with histologically proven low-grade NHL, and seventy-four with a high-grade subtype. Results: sCA125 and LDH levels were elevated in more than one third of patients. sCA125 was more frequently increased than LDH in low-grade NHL. In this group, complete remission (CR) was achieved in 87, 45, and 0% (P - < 2 x 10~ 6 ) of patients with normal sCA125 and LDH serum levels (Low-risk group), one parameter increased (Intermediate-risk group), and increased sCA125 and LDH serum levels (high-risk group), respectively. The estimated five-year overall survival was 97%, 67% and 22% for low, intermediate, and high-risk groups, respectively. This combination was the only parameter predictive of RFS and OS in multivariate analysis (P < 0.0001). Conclusions: In this study the combination of s-LDH and sCA125 levels (normal vs. abnormal) was found to be an important prognostic factor in low-grade lymphoma and may be used in the selection of appropriate therapeutic approaches for individual patients. |
Databáze: | OpenAIRE |
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