Continuous Processing and Efficient $\textit{in Situ}$ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy

Autor: Ahmed-Omer, B, Sliwinski, E, Cerroti, JP, Ley, SV
Přispěvatelé: Ley, Steven [0000-0002-7816-0042], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Popis: Real-time NMR spectroscopy has proven to be a rapid and an effective monitoring tool to study the hypervalent iodine(III) mediated cyclopropanation. With the ever increasing number of new synthetic methods for carbon−carbon bond formation, the NMR $\textit{in situ}$ monitoring of reactions is becoming a highly desirable enabling method. In this study, we have demonstrated the versatility of benchtop NMR using inline and online real-time monitoring methods to access mutually complementary information for process understanding, and we developed new approaches for real-time monitoring addressing challenges associated with better integration into continuous processes.
Databáze: OpenAIRE