Small Animal In Vivo X-Ray Tomosynthesis: Anatomical Relevance of the Reconstructed Images
| Autor: | H. Barquero, D. Brasse |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Image processing
Iterative reconstruction 01 natural sciences Imaging phantom 030218 nuclear medicine & medical imaging 010309 optics Mice 03 medical and health sciences 0302 clinical medicine 0103 physical sciences Image Processing Computer-Assisted Medical imaging Animals Computer vision Electrical and Electronic Engineering Mathematics Radiological and Ultrasound Technology Phantoms Imaging business.industry Reconstruction algorithm X-Ray Microtomography Image segmentation Thresholding Tomosynthesis Computer Science Applications Artificial intelligence business Algorithms Software |
| Zdroj: | IEEE Transactions on Medical Imaging. 35:373-380 |
| ISSN: | 1558-254X 0278-0062 |
| DOI: | 10.1109/tmi.2015.2471075 |
| Popis: | Whole body X-ray micro-Digital Tomosynthesis (micro-DT) for small animal imaging is introduced in this work. Such a system allows to deal with geometrical constraints that do not allow to use a micro-CT system as well as to reduce the radiological dose compared to a micro-CT scan. Data was simulated using the Digimouse anatomical model of the mouse with the designed system. An algebraic reconstruction algorithm regularized by Total Variation norm (TV) minimization was used to reconstruct images. Parameters for the reconstruction were optimized and the algorithm performance was evaluated quantitatively. High contrast tissues were subsequently segmented by thresholding the image. Quantitative analysis of the segmented domains indicates that a relevant anatomical information can possibly be extracted from micro-DT images. Indeed the Dice's coefficient values are greater than 0.8 for the segmented High Contrast Tissues compared to the phantom, which indicates an important overlap between the domains. The volume of the segmented tissues is over-estimated for the bones and skin—with 1.313 and 1.113 ratios of the estimated over reference volumes, respectively—and under-estimated in the case of the lungs with a 0.762 ratio. The mean point to surface distance is inferior to the voxel size of 400 $\mu{\rm m}$ , for the three segmented tissues. These results are very encouraging and let us consider micro-DT as an alternative to micro-CT to deal with geometrical constraints. |
| Databáze: | OpenAIRE |
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