Diagnosis and clinical associations of zinc depletion following bone marrow transplantation
| Autor: | Alexandra Papadopoulou, M D Williams, K Nathavitharana, P J Darbyshire, I W Booth |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Phosphoric monoester hydrolases Adolescent Fever chemistry.chemical_element Zinc Sensitivity and Specificity Internal medicine medicine Humans Prospective Studies Child Bone Marrow Transplantation Anthropometry Nutritional Support business.industry Infant Alkaline Phosphatase medicine.disease Low alkaline phosphatase Diarrhea medicine.anatomical_structure Endocrinology chemistry Child Preschool Pediatrics Perinatology and Child Health Immunology Zinc deficiency Alkaline phosphatase Female Bone marrow medicine.symptom Complication business Biomarkers Research Article |
| Zdroj: | Archives of Disease in Childhood. 74:328-331 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.74.4.328 |
| Popis: | Following the emergence of biochemical zinc deficiency after bone marrow transplantation, the clinical value of plasma alkaline phosphatase activity as an early indicator of biochemical zinc depletion was investigated in this group of patients. Serial measurements of plasma zinc and alkaline phosphatase activities in 28 consecutive children (median age 8.7 years; 16 males) undergoing bone marrow transplantation were carried out and clinical associations recorded. A significant fall in plasma zinc occurred after the bone marrow transplant, and 19 children developed biochemical zinc deficiency (Zn < 11 mumol/l) at a median of 7 days following the transplant. Zinc depletion was more common in younger patients and in children with diarrhoea. A positive correlation was found between plasma zinc and alkaline phosphatase activities. Zinc depleted patients had more febrile episodes of longer duration and were more likely to have a positive blood culture. Haemopoetic recovery was not affected by zinc deficiency. Following zinc supplementation, alkaline phosphatase showed a significant increase. The sensitivity of a low alkaline phosphatase as a screening test for biochemical zinc deficiency was 83%, with a specificity of 86%. Low alkaline phosphatase activity following bone marrow transplant is an indication for zinc supplements. |
| Databáze: | OpenAIRE |
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