Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients
| Autor: | Antonio Carannante, Alessio Rodolico, Luisa Aran, Alessandra Cuomo, Michele Russo, Gilda Varricchi, Giacomo Campi, Galdieri A, Carlo G. Tocchetti, Dalila Bruno, Umberto Attanasio, Mercurio, Riccardo Franco |
|---|---|
| Přispěvatelé: | Mercurio, Valentina, Varricchi, Gilda, Tocchetti, Carlo G, Attanasio, Umberto, Carannante, Antonio, Aran, Luisa, Bruno, Dalila, Franco, Riccardo, Campi, Giacomo, Russo, Michele, Galdieri, Amalia, Rodolico, Alessio, Cuomo, Alessandra |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cardiovascular toxicity
medicine.medical_specialty medicine.medical_treatment heart failure 030204 cardiovascular system & hematology Biological drugs 03 medical and health sciences 0302 clinical medicine HER2 Cardiovascular problems Medicine Diseases of the circulatory (Cardiovascular) system Intensive care medicine Co-Morbidities anthracyclines Cardiotoxicity business.industry Cancer Immunotherapy medicine.disease VEGF immunotherapy 030220 oncology & carcinogenesis Heart failure RC666-701 Anticancer drugs-induced cardiotoxicity Cardiology and Cardiovascular Medicine business After treatment |
| Zdroj: | Cardiac Failure Review, Vol 5, Iss 2, Pp 112-118 (2019) Cardiac Failure Review |
| ISSN: | 2057-7540 2057-7559 |
| Popis: | Although there have been many improvements in prognosis for patients with cancer, anticancer therapies are burdened by the risk of cardiovascular toxicity. Heart failure is one of the most dramatic clinical expressions of cardiotoxicity, and it may occur acutely or appear years after treatment. This article reviews the main mechanisms and clinical presentations of left ventricular dysfunction induced by some old and new cardiotoxic drugs in cancer patients, referring to the most recent advances in the field. The authors describe the mechanisms of cardiotoxicity induced by anthracyclines, which can lead to cardiovascular problems in up to 48% of patients who take them. The authors also describe mechanisms of cardiotoxicity induced by biological drugs that produce left ventricular dysfunction through secondary mechanisms. They outline the recent advances in immunotherapies, which have revolutionised anticancer therapies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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