The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice
| Autor: | Wei-Min Qu, Yu-Dong Yan, Ya-Nan Zhao, Su-Rong Yang, Chen-Yao Wang, Thomas C. Jhou, Zhi-Li Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
rostromedial tegmental nucleus
media_common.quotation_subject Review 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Dopamine medicine sleep–wake behavior Exact location anatomical location Applied Psychology media_common projections business.industry Addiction Dopaminergic Sleep in non-human animals Ventral tegmental area medicine.anatomical_structure nervous system 030228 respiratory system Rostromedial tegmental nucleus addiction Aversive Stimulus business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Nature and Science of Sleep |
| ISSN: | 1179-1608 |
| Popis: | The rostromedial tegmental nucleus (RMTg), a brake of the dopamine system, is specifically activated by aversive stimuli, such as foot shock. It is principally composed of gamma-aminobutyric acid neurons. However, there is no exact location of the RMTg on the brain stereotaxic atlas. The RMTg can be defined by c-Fos staining elicited by psychostimulants, the position of retrograde-labeled neurons stained by injections into the ventral tegmental area (VTA), the terminal field formed by axons from the lateral habenula, and some molecular markers identified as specifically expressed in the RMTg such as FoxP1. The RMTg receives a broad range of inputs and produces diverse outputs, which indicates that the RMTg has multiple functions. First, the RMTg plays an essential role for non-rapid eye movement sleep. Additionally, the RMTg serves a vital role in response to addiction. Opiates increase the firing rates of dopaminergic neurons in the VTA by acting on μ-opioid receptors on RMTg neurons and their terminals inside the VTA. In this review, we summarize the recent research advances on the anatomical location of the RMTg in rats and mice, its projections, and its regulation of sleep–wake behavior and addiction. |
| Databáze: | OpenAIRE |
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