Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands
| Autor: | Jeannette M. Watson, Simon E. Ward |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Molecular Structure
Stereoisomerism General Medicine Computational biology Serotonin 5-HT1 Receptor Agonists Serotonin 5-HT1 Receptor Antagonists Pharmacology Biology Ligands Partial agonist Serotonin Receptor Agonists Structure-Activity Relationship Receptor Serotonin 5-HT1D Drug Discovery Humans Serotonin Antagonists 5-HT1D receptor Clinical evaluation |
| Zdroj: | Current Topics in Medicinal Chemistry. 10:479-492 |
| ISSN: | 1568-0266 |
| Popis: | This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT(1D) receptor. The field of 5-HT(1D) agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT(1D) receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|