Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats
| Autor: | B Rubin, Don N. Harris, M J Antonaccio, M Waugh, R A Ferrone |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic nervous system Captopril Hypertension Renal Sympathetic Nervous System Blood Pressure Plasma renin activity Hydroxydopamines Renal Artery Internal medicine medicine.artery Adrenal Glands Renin Renin–angiotensin system Internal Medicine medicine Animals Renal artery business.industry Angiotensin II Constriction Rats medicine.anatomical_structure Endocrinology Blood pressure Adrenal Medulla business Adrenal medulla medicine.drug |
| Zdroj: | Hypertension. 2:723-781 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.2.6.723 |
| Popis: | The relative roles of the sympathetic nervous system and renin-angiotensin system in the development of two-kidney renal hypertension were studied using four groups of rats: Group I = vehicle control; Group II = 6-OH-dopamine (2 weeks prior to renal clipping then weekly throughout the study); Group III = adrenal medullectomy plus vehicle; Group IV = 6-OH-dopamine plus adrenal medullectomy. Six weeks after clipping of a single renal artery, plasma renin activity (PRA) was comparably elevated in all groups. However, mean blood pressure (MBP) of Group II was lower than that of Group I controls (154.7 +/- 6.8 vs 197.3 +/- 6.6 mm Hg respectively). The MBP of Group III (207.0 +/- 5.2 mm Hg) was not different from that of Group I whereas in Group IV (134.2 +/- 18.0 mm Hg) it was markedly lower. All groups of rats were given a single dose of captopril (30 mg/kg p.o.) to inhibit the renin-angiotensin system. Despite differences in starting MBP, captopril caused similar reductions (38-50%) of MBP and increases in PRA in all groups. Similar results were obtained in two-kidney renal hypertensive rats with hypertension of 12 weeks' duration. It is concluded that the sympathetic nervous system does not contribute to the elevated PRA in two-kidney renal hypertensive rats but does contribute significantly to the development of hypertension in this model. |
| Databáze: | OpenAIRE |
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