Effects of dietary cold-pressed turnip rapeseed oil and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome
| Autor: | Hanna Pohjantähti-Maaroos, Kalevi Oksanen, J.-M. Pihlava, Päivi Kankkunen, Sari Husgafvel, Ari Palomäki, Marja Wallenius, H. Aro |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Rapeseed Clinical chemistry Endocrinology Diabetes and Metabolism Clinical Biochemistry Administration Oral Blood lipids Clinical nutrition Fatty Acids Monounsaturated chemistry.chemical_compound Endocrinology Fatty Acids Omega-3 medicine Humans Plant Oils Food science lcsh:RC620-627 Aged Metabolic Syndrome Biochemistry medical chemistry.chemical_classification business.industry Cholesterol Research Brassica napus Cholesterol HDL Biochemistry (medical) food and beverages Arteries Cholesterol LDL Middle Aged medicine.disease Elasticity Diet Europe Lipoproteins LDL lcsh:Nutritional diseases. Deficiency diseases chemistry Biochemistry Butter Rapeseed Oil lipids (amino acids peptides and proteins) Metabolic syndrome business Polyunsaturated fatty acid Lipidology |
| Zdroj: | Lipids in Health and Disease, Vol 9, Iss 1, p 137 (2010) Lipids in Health and Disease |
| Popis: | Background Rapeseed oil is the principal dietary source of monounsaturated and n-3 polyunsaturated fatty acids in the Northern Europe. However, the effect of rapeseed oil on the markers of subclinical atherosclerosis is not known. The purpose of this study was to compare the effects of dietary intake of cold-pressed turnip rapeseed oil (CPTRO) and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome. Methods Thirty-seven men with metabolic syndrome completed an open and balanced crossover study. Treatment periods lasted for 6 to 8 weeks and they were separated from each other with an eight-week washout period. Subjects maintained their normal dietary habits and physical activity without major variations. The daily fat adjunct consisted either of 37.5 grams of butter or 35 mL of VirginoR CPTRO. Participants were asked to spread butter on bread on the butter period and to drink CPTRO on the oil period. The fat adjunct was used as such without heating or frying. Results Compared to butter, administration of CPTRO was followed by a reduction of total cholesterol by 8% (p < 0.001) and LDL cholesterol by 11% (p < 0.001). The level of oxidized LDL was 16% lower after oil period (p = 0.024). Minimal differences in arterial elasticity were not statistically significant. Conclusion Cold-pressed turnip rapeseed oil had favourable effects on circulating LDL cholesterol and oxidized LDL, which may be important in the management of patients at high cardiovascular risk. Trial registration ClinicalTrial.gov NCT01119690 |
| Databáze: | OpenAIRE |
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