Effect of carotid artery ligation on regional cerebral blood flow in normotensive and spontaneously hypertensive rats
| Autor: | Takeya Y, J I Choki, Teruo Omae, Yamaguchi T, Morotomi Y |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Artificial ventilation
medicine.medical_specialty Carotid arteries medicine.medical_treatment Ischemia Blood Pressure Internal medicine Medicine Animals cardiovascular diseases Pulse Ligation Advanced and Specialized Nursing business.industry Hydrogen-Ion Concentration musculoskeletal system medicine.disease Rats Blood pressure Carotid Arteries Cerebral blood flow Ischemic Attack Transient Cerebrovascular Circulation Hypertension cardiovascular system Cardiology Autoradiography Female Neurology (clinical) Blood Gas Analysis Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Zdroj: | Acta neurologica Scandinavica. Supplementum. 64 |
| ISSN: | 0065-1427 |
| Popis: | Regional cerebral blood flow (rCBF) was measured in normotensive rate (NTR) and spontaneously hypertensive rats (SHR), in a lightly anesthetized state and with control of PaCO2 by artificial ventilation. Without carotid artery ligation, NTR and SHR showed almost identical rCBF values and distribution, despite significantly elevated levels of blood pressure in SHR. Bilateral carotid artery ligation, however, caused much more pronounced decreases of rCBF (ischemia) in SHR than NTR, in regions supplied by the carotid artery. The reduction of rCBF in SHR was rather homogenous and symmetrical. Mechanisms causing the differences between NTR and SHR are discussed. |
| Databáze: | OpenAIRE |
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