Alcohol consumption and breast cancer risk by estrogen receptor status: in a pooled analysis of 20 studies
| Autor: | Marian L. Neuhouser, Julie E. Buring, Laurence N. Kolonel, Molin Wang, Roni T. Falk, Kim Robien, Judith Hoffman-Bolton, Kristin E. Anderson, Paige Maas, Lynne R. Wilkens, Manami Inoue, Susan M. Gapstur, Regina G. Ziegler, Victoria L. Stevens, Xuehong Zhang, Leslie Bernstein, Seungyoun Jung, Stephanie A. Smith-Warner, Thomas E. Rohan, Gary E. Goodman, Laura Baglietto, Leo J. Schouten, Louise A. Brinton, Anne Zeleniuch-Jacquotte, Graham G. Giles, A. Heather Eliassen, Sabina Sieri, Shumin M. Zhang, Elisabete Weiderpass, Alicja Wolk, Stephanie Scarmo, Walter C. Willett, Anthony B. Miller, Yikyung Park, Pamela L. Horn-Ross, Vittorio Krogh, Kala Visvanathan, Piet A. van den Brandt, S. Tsugane, Leif Bergkvist, Marie Löf |
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| Přispěvatelé: | Epidemiologie, RS: GROW - R1 - Prevention, RS: CAPHRI - R5 - Optimising Patient Care |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Alcohol breast cancer cohort study epidemiology estrogen receptor folate pooled analyses progesterone receptor Estrogen receptor 0302 clinical medicine Risk Factors Surveys and Questionnaires Prospective Studies 030212 general & internal medicine skin and connective tissue diseases Prospective cohort study Estrogen Receptor Status Aged 80 and over General Medicine Middle Aged Progesterone Receptor Status Receptors Estrogen 030220 oncology & carcinogenesis Female Other Health-related Behaviours and Cancer Adult medicine.medical_specialty Alcohol Drinking Breast Neoplasms Young Adult 03 medical and health sciences Folic Acid Breast cancer Internal medicine medicine Humans Aged Proportional Hazards Models Ethanol Proportional hazards model business.industry Cancer medicine.disease Endocrinology Relative risk Dietary Supplements Multivariate Analysis business |
| Zdroj: | International Journal of Epidemiology, 45(3), 916-928. Oxford University Press |
| ISSN: | 0300-5771 |
| Popis: | Background Breast cancer aetiology may differ by estrogen receptor (ER) status. Associations of alcohol and folate intakes with risk of breast cancer defined by ER status were examined in pooled analyses of the primary data from 20 cohorts. Methods During a maximum of 6-18 years of follow-up of 1 089 273 women, 21 624 ER+ and 5113 ER- breast cancers were identified. Study-specific multivariable relative risks (RRs) were calculated using Cox proportional hazards regression models and then combined using a random-effects model. Results Alcohol consumption was positively associated with risk of ER+ and ER- breast cancer. The pooled multivariable RRs (95% confidence intervals) comparing ≥ 30 g/d with 0 g/day of alcohol consumption were 1.35 (1.23-1.48) for ER+ and 1.28 (1.10-1.49) for ER- breast cancer (Ptrend ≤ 0.001; Pcommon-effects by ER status: 0.57). Associations were similar for alcohol intake from beer, wine and liquor. The associations with alcohol intake did not vary significantly by total (from foods and supplements) folate intake (Pinteraction ≥ 0.26). Dietary (from foods only) and total folate intakes were not associated with risk of overall, ER+ and ER- breast cancer; pooled multivariable RRs ranged from 0.98 to 1.02 comparing extreme quintiles. Following-up US studies through only the period before mandatory folic acid fortification did not change the results. The alcohol and folate associations did not vary by tumour subtypes defined by progesterone receptor status. Conclusions Alcohol consumption was positively associated with risk of both ER+ and ER- breast cancer, even among women with high folate intake. Folate intake was not associated with breast cancer risk. |
| Databáze: | OpenAIRE |
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