Effects of actinomycin D on the lysosomes of newborn rat hepatocytes
| Autor: | O. B. Kotoulas |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Biology
chemistry.chemical_compound Protein biosynthesis Animals Glycoside Hydrolase Inhibitors chemistry.chemical_classification Glycogen Glucosidase activity Catabolism Lysosomes/*drug effects/ultrastructure Liver/enzymology Liver Glycogen/*metabolism Rats Inbred Strains alpha-Glucosidases alpha-Glucosidases/*antagonists & inhibitors/metabolism Dactinomycin/*pharmacology Agricultural and Biological Sciences (miscellaneous) Molecular biology Liver Glycogen Rats Enzyme Biochemistry chemistry Animals Newborn Liver Rat liver Dactinomycin Anatomy Maltase Lysosomes |
| Zdroj: | The Anatomical record. 220(1) |
| ISSN: | 0003-276X |
| Popis: | The effects of actinomycin D on newborn rat liver were studied by using biochemical assays, electron microscopy, and quantitative morphometry. Actinomycin prevented the normal postnatal rise in acid a 1,4 glucosidase (maltase) activity and the breakdown of lysosomal glycogen. The results suggest that the postnasal increase in acid glucosidase activity is protein synthesis dependent. This enzyme is critical for the catabolism of the lysosomal glycogen in newborn rat hepatocytes. Anat Rec |
| Databáze: | OpenAIRE |
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