Application of carboxylic-phospholanic mixed anhydrides to fragment coupling in peptide synthesis
| Autor: | Oluyinka M. Ogunjobi, Constantine Poulos, Robert Ramage, Jeremy Green, Chris P. Ashton, Theodoros Tsegenidis |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Magnetic Resonance Spectroscopy Molecular Structure Stereochemistry Carboxylic Acids Oxazolone Phosphorus Peptide Tripeptide Nuclear magnetic resonance spectroscopy Phosphinic Acids Biochemistry Peptide Fragments Anhydrides chemistry.chemical_compound chemistry Reagent Phase (matter) Polymer chemistry Peptide synthesis Peptide bond Reactivity (chemistry) Peptides |
| Zdroj: | International Journal of Peptide and Protein Research. 40:315-321 |
| ISSN: | 0367-8377 |
| Popis: | The application of 1-oxo-1-chlorophospholane as a novel reagent for the in situ activation of peptide fragments for use in peptide bond forming reactions, either in liquid or solid phase, has been examined. 24.1 MHz 31P NMR spectroscopy has been employed to follow the formation, stability and reactivity of the intermediate phospholanic-carboxylic mixed anhydride. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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