Assessment of Remote Myocardium Heterogeneity in Patients with Ventricular Tachycardia Using Texture Analysis of Late Iodine Enhancement (LIE) Cardiac Computed Tomography (cCT) Images

Autor: Antonio Esposito, Paolo Della Bella, Francesca Baratto, Anna Palmisano, Caterina Colantoni, Sofia Antunes, Davide Vignale, Paola M.V. Rancoita, Francesco De Cobelli, Alessandro Del Maschio
Přispěvatelé: Esposito, Antonio, Palmisano, Anna, Antunes, Sofia, Colantoni, Caterina, Rancoita, Paola Maria Vittoria, Vignale, Davide, Baratto, Francesca, Della Bella, Paolo, Del Maschio, Alessandro, De Cobelli, Francesco
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Radiology
Nuclear Medicine and Imaging
Cancer Research
Myocarditis
Cardiac computed tomography
030204 cardiovascular system & hematology
Ventricular tachycardia
Myocardial characterization
030218 nuclear medicine & medical imaging
Late iodine enhancement
03 medical and health sciences
Electrocardiography
0302 clinical medicine
Internal medicine
Hounsfield scale
Idiopathic dilated cardiomyopathy
medicine
Humans
Radiology
Nuclear Medicine and imaging
Aged
Ejection fraction
medicine.diagnostic_test
business.industry
Myocardium
Dilated cardiomyopathy
Middle Aged
medicine.disease
Image Enhancement
medicine.anatomical_structure
Oncology
Ventricle
Extracellular volume fraction
Cardiology
Tachycardia
Ventricular
Female
Heterogeneity
business
Tomography
X-Ray Computed
Research Article
Iodine
Zdroj: Molecular Imaging and Biology
ISSN: 1860-2002
1536-1632
Popis: Purpose: Diffuse remodeling of myocardial extra-cellular matrix is largely responsible for left ventricle (LV) dysfunction and arrhythmias. Our hypothesis is that the texture analysis of late iodine enhancement (LIE) cardiac computed tomography (cCT) images may improve characterization of the diffuse extra-cellular matrix changes. Our aim was to extract volumetric extracellular volume (ECV) and LIE texture features of non-scarred (remote) myocardium from cCT of patients with recurrent ventricular tachycardia (rVT), and to compare these radiomic features with LV-function, LV-remodeling, and underlying cardiac disease. Procedures: Forty-eight patients suffering from rVT were prospectively enrolled: 5/48 with idiopathic VT (IVT), 23/48 with post-ischemic dilated cardiomyopathy (ICM), 9/48 with idiopathic dilated cardiomyopathy (IDCM), and 11/48 with scars from a previous healed myocarditis (MYO). All patients underwent echocardiography to assess LV systolic and diastolic function and cCT with pre-contrast, angiographic, and LIE scan to obtain end-diastolic volume (EDV), ECV, and first-order texture parameters of Hounsfield Unit (HU) of remote myocardium in LIE [energy, entropy, HU-mean, HU-median, standard deviation (SD), and mean absolute deviation (MAD)]. Results: Energy, HU mean, and HU median by cCT texture analysis correlated with ECV (rho = 0.5650, rho = 0.5741, rho = 0.5068; p < 0.0005). cCT-derived ECV, HU-mean, HU-median, SD, and MAD correlated directly to EDV by cCT and inversely to ejection fraction by echocardiography (p < 0.05). SD and MAD correlated with diastolic function by echocardiography (rho = 0.3837, p = 0.0071; rho = 0.3330, p = 0.0208). MYO and IVT patients were characterized by significantly lower values of SD and MAD when compared with ICM and IDCM patients, independently of LV-volume systolic and diastolic function. Conclusions: Texture analysis of LIE may expand cCT capability of myocardial characterization. Myocardial heterogeneity (SD and MAD) was associated with LV dilatation, systolic and diastolic function, and is able to potentially identify the different patterns of structural remodeling characterizing patients with rVT of different etiology.
Databáze: OpenAIRE
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