Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis
| Autor: | Antonio Carotenuto, Marcello Moccia, Gilda Cennamo, Chiara Criscuolo, Federica Sparnelli, Vincenzo Brescia Morra, Roberta Lanzillo, Alessandra Cianflone, Nunzio Velotti |
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| Přispěvatelé: | Lanzillo, Roberta, Cennamo, Gilda, Criscuolo, Chiara, Carotenuto, Antonio, Velotti, Nunzio, Sparnelli, Federica, Cianflone, Alessandra, Moccia, Marcello, Brescia Morra, Vincenzo |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Optic Neuritis Retinal vascular abnormalitie genetic structures optical coherence tomography angiography Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nerve Fibers Optical coherence tomography medicine Humans Fluorescein Angiography medicine.diagnostic_test business.industry Multiple sclerosis Retinal Optical coherence tomography angiography Middle Aged medicine.disease eye diseases Neurology chemistry Vascular network multiple sclerosi Angiography 030221 ophthalmology & optometry Female sense organs Neurology (clinical) Radiology business 030217 neurology & neurosurgery Tomography Optical Coherence |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England). 24(13) |
| ISSN: | 1477-0970 |
| Popis: | Background: Optical coherence tomography (OCT) angiography is a new method to assess the density of the vascular networks. Vascular abnormalities are considered involved in multiple sclerosis (MS) pathology. Objective: To assess the presence of vascular abnormalities in MS and to evaluate their correlation to disease features. Methods: A total of 50 MS patients with and without history of optic neuritis (ON) and 46 healthy subjects were included. All underwent spectral domain (SD)-OCT and OCT angiography. Clinical history, Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS) and disease duration were collected. Results: Angio-OCT showed a vessel density reduction in eyes of MS patients when compared to controls. A statistically significant reduction in all SD-OCT and OCT angiography parameters was noticed both in eyes with and without ON when compared with control eyes. We found an inverse correlation between SD-OCT parameters and MSSS ( p = 0.003) and between vessel density parameters and EDSS ( p = 0.007). Conclusion: We report a vessel density reduction in retina of MS patients. We highlight the clinical correlation between vessel density and EDSS, suggesting that angio-OCT could be a good marker of disease and of disability in MS. |
| Databáze: | OpenAIRE |
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