Antidiabetic effects of Salvia triloba and Thymus praecox subsp. skorpilii var. skorpilii in a rat model of streptozotocin/nicotinamide-induced diabetes
| Autor: | Muhammet Emin Cam, Levent Kabasakal, Ayşe Eda Acar, Turgut Taşkın, Sila Yildiz, Büşra Ertaş |
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| Přispěvatelé: | Cam, Muhammet Emin, Yildiz, Sila, Ertas, Busra, Acar, Ayse Eda, Taskin, Turgut, Kabasakal, Levent |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
endocrine system diseases
Type II diabetes mellitus Rat model 02 engineering and technology Pharmacology Salvia 010402 general chemistry 01 natural sciences chemistry.chemical_compound Diabetes mellitus medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Salvia triloba Traditional medicine biology Nicotinamide Chemistry antidiabetic ALLOXAN Insulin tolerance test Streptozotocin nicotinamide 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification Streptozotocin 0104 chemical sciences Thymus praecox herbal medicines Lamiaceae Streptozotocin-Nicotinamide 0210 nano-technology medicine.drug |
| Popis: | Some Salvia and Thymus species of Lamiaceae family come into prominence with strong antidiabetic effects. Compared to the other species, there are limited studies on antidiabetic activity of Salvia triloba (ST) and Thymus praecox subsp. skorpilii var. skorpilii (TPS). The aim of this study was to adjust the dosage and to determine the antidiabetic effects of methanol extracts of ST and TPS in streptozotocin/nicotinamide-induced diabetic rats. Type II diabetes mellitus (T2DM) was induced by a single intraperitoneal (i. p.) injection of streptozotocin (STZ) dissolved in 0.1 M cold citrate buffer (pH 4.5) at a dose of 55 mg/kg/body weight (b.w.) and nicotinamide (100 mg/kg/b.w.) was given prior to STZ injection. For adjusting dosage, oral glucose tolerance test (OGTT) was used while insulin tolerance test (ITT), OGTT, blood glucose levels and animal weights were used to evaluate the antidiabetic effects of ST and TPS. According to the OGTT, the most effective doses for ST and TPS were 200 mg/kg and 100 mg/kg, respectively. At the end of three weeks, blood glucose levels of control goup reached to 462.50 mg/dl, whereas ST and TPS-treated groups blood glucose levels decreased less than 200.00 mg/dl. In conclusion, the present study suggests that both of ST and TPS methanolic extracts may be of therapeutic benefit in diabetes and thus need to further studies. |
| Databáze: | OpenAIRE |
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