Androgenic effects of aqueous and methanolic extracts of Ficus asperifolia in male Wistar rats
| Autor: | Pepin Alango Nkeng-Efouet, Albert Kamanyi, Esther Ngadjui, Hermine Meli Watio, Télesphore Benoît Nguelefack, Modeste Wankeu-Nya, Pierre Watcho, Patrick Brice Deeh Defo |
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| Jazyk: | angličtina |
| Předmět: |
Testosterone propionate
Male medicine.medical_specialty Ficus Stimulation 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bicalutamide Internal medicine Androgen deficiency Testis medicine Animals Testosterone Rats Wistar Ficus asperifolia 030219 obstetrics & reproductive medicine biology Cholesterol business.industry Plant Extracts Vas deferens General Medicine Organ Size biology.organism_classification Epididymis medicine.disease 0104 chemical sciences Rats 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Endocrinology chemistry Complementary and alternative medicine Androgens Rat business Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/s12906-016-1547-5 |
| Popis: | Background Androgen deficiency is a clinical syndrome resulting from the inability of the testes to produce physiological levels of testosterone due to a disturbance occurring at one or more levels of the hypothalamic-pituitary-testicular axis. The present study was undertaken to evaluate the androgenic properties of aqueous and methanolic extracts of Ficus asperifolia on normal and castrated immature rats. Methods Normal rats were treated either per os with aqueous or methanolic extract of Ficus asperifolia (100 mg/kg or 500 mg/kg b.w.), distilled water (10 ml/kg b.w.), 5% Tween 80 (10 ml/kg b.w.) or subcutaneously with testosterone propionate (0.5 mg/kg b.w.). Castrated rats were treated with plant extracts (100 mg/kg b.w. or 500 mg/kg b.w.) alone or with the co-administration of plant extracts and testosterone propionate (s.c., 0.5 mg/kg b.w.) or bicalutamide (2 mg/kg b.w. per os). Animals were treated once a day during four weeks. Body weight growth and relative sexual organ weights were recorded at the end of each treatment. Some biomedical parameters were measured in the plasma (proteins, cholesterol), testes (cholesterol) and epididymis (proteins). Results In normal rats, Ficus asperifolia significantly (p |
| Databáze: | OpenAIRE |
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