Increased Serum miR-206 Level Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer’s Disease: A 5-Year Follow-up Study

Autor: Zanchao Liu, Shunjiang Xu, Lei Jiang, Xueyi Wang, Mei Song, Bing Xie, Rui Zhang, Wei Liu, Dongsheng Cui, Qingfu Zhang
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Oncology
Circulating mirnas
Pathology
medicine.medical_specialty
Time Factors
5 year follow up
Disease
Neuropsychological Tests
behavioral disciplines and activities
Cohort Studies
Correlation
03 medical and health sciences
0302 clinical medicine
Sirtuin 1
Alzheimer Disease
Internal medicine
mental disorders
medicine
Humans
Cognitive Dysfunction
Elisa method
Cognitive impairment
Survival analysis
Aged
Proportional Hazards Models
Aged
80 and over
Proportional hazards model
Brain-Derived Neurotrophic Factor
General Neuroscience
General Medicine
Mental Status and Dementia Tests
Survival Analysis
MicroRNAs
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Disease Progression
Female
Geriatrics and Gerontology
Psychology
030217 neurology & neurosurgery
Zdroj: Journal of Alzheimer's Disease. 55:509-520
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-160468
Popis: Evidence suggests that individuals with amnestic mild cognitive impairment (aMCI) tend to progress to probable Alzheimer's disease (AD) with aging. This study was performed to examine whether circulating miRNAs could be potential predictors for the progression of aMCI to AD. A total of 458 patients with aMCI were included in this study, and the clinical data were collected at two time points: the baseline and the follow-up assessment. These aMCI patients were classified into two groups after 5 years: aMCI-stable group (n = 330) and AD-conversion group (n = 128). The expression of miR-206 and miR-132 and the levels of BDNF and SIRT1 in serum were detected using a quantitative real-time RT-PCR (qPCR) and the ELISA method, respectively. Kaplan-Meier method (Log-rank test) was used for univariate survival analysis. Cox proportional hazard model was used to estimate the prognostic value of miRNAs in conversion from aMCI to AD. At the baseline, serum levels of miR-206 in aMCI-AD group were significantly elevated compared to aMCI-aMCI group and the same trend was found at 5-year follow-up time point as well. There were no significant differences in serum levels of miR-132 between the conversion and non-conversion group at both time points. Kaplan-Meier analysis showed significant correlation between AD conversion and higher serum levels of miR-206 for aMCI patients (HR = 3.60, 95% CI: 2.51- 5.36, p < 0.001). Multivariate Cox regression analysis revealed that serum miR-206 and its target BDNF were significant independent predictors for AD conversion (HR = 4.22, p < 0.001). These results suggested that increased serum miR-206 level might be a potential predictor of conversion from aMCI to AD.
Databáze: OpenAIRE
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