Effectiveness of thiamine therapy in mortality rate in patients with septic shock: A systematic review and meta-analysis
| Autor: | Sukrit Kanchanasurakit, Chansinee Srisawat, Wichai Santimaleeworagun, Surasak Saokaew, Virakarn Chirakan, Monnaree Nunta, Pornsinee Suthumpoung, Chotirat Nakaranurack, Nina S Huynh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Funnel plot Septic shock business.industry Mortality rate Public Health Environmental and Occupational Health Publication bias Critical Care and Intensive Care Medicine medicine.disease law.invention thiamine Randomized controlled trial law Internal medicine Meta-analysis Relative risk Emergency Medicine medicine septic shock Thiamine Original Article Mortality business |
| Zdroj: | International Journal of Critical Illness and Injury Science |
| ISSN: | 2231-5004 2229-5151 |
| Popis: | Background Septic shock is a serious condition leading to increased mortality. Despite previous report of no benefit, thiamine has emerged as potential therapy to reduce mortality in septic shock patients. This study aimed to investigate the effect of thiamine in mortality rate in patients with septic shock. Methods Eight databases, including MEDLINE, EMBASE, Science Direct, Scopus, Cochrane, CINAHL, Open Grey, and Dart-Europe, were systematically searched from the inception of the database up to August 21, 2020. Studies evaluating the effectiveness of thiamine on mortality rate in septic shock patients compared between thiamine and placebo were included. We used random-effects model to analyze the mortality with risk ratio (RR) and 95% confidence interval (95% CI). The subgroup and sensitivity analysis were performed to examine the influence of variables. Publication bias was considered using funnel plot, Begg's test, and Egger's test. Results A total of 3,658 studies were retrieved and reviewed. Five studies were included for meta-analysis. In random-effects meta-analysis of the randomized controlled trials, although not statistically significant, there was a trend which suggested that thiamine may reduce mortality rate in septic shock patients (RR, 0.96; 95% CI: 0.72-1.28, P = 0.774). The result of sensitivity and subgroup analyses also supported the suggestion that thiamine may decrease mortality in septic shock patients. The Begg's test (P = 0.624) and Egger's test (P = 0.777) revealed no publication bias. Conclusions Although not statistically significant, thiamine may reduce mortality rate in septic shock patients. Further prospective studies with larger sample size are warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|